4-(1-丁基-1-(E)-戊烯基)吗啉 | 110684-91-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: 4-(1-丁基-1-(E)-戊烯基)吗啉
• 英文名称: 4-(1-butyl-1(E)-pentenyl)morpholine
• 英文别名: (E)-5-morpholino-4-nonene；(E)-5-(4-morpholino)-4-nonene；4-[(E)-non-4-en-5-yl]morpholine
• CAS: 110684-91-8
• 化学式: C₁₃H₂₅NO
• 分子量: 211.348
• InChiKey: RFWVDFZECSHJGZ-NTUHNPAUSA-N

物化性质

• 沸点：
  305.6±31.0 °C(Predicted)
• 密度：
  0.912±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(1-丁基-1-(E)-戊烯基)吗啉 以29%的产率得到
  参考文献：
  名称：

  Goralski Christian T., Hasha Dennis L., Nicholson Lawrence W., Zakett Don+, Tetrahedron Lett, 35 (1994) N 20, S 3251-3254

  摘要：

  DOI：
• 作为产物：
  描述：

  5-壬酮 、 吗啉 生成 4-(1-丁基-1-(E)-戊烯基)吗啉
  参考文献：
  名称：

  ANGOH, A. G.;CLIVE, D. L. J., J. CHEM. SOC. CHEM. COMMUN., 1985, N 14, 941-942

  摘要：

  DOI：

文献信息

• Boranes in synthesis. 3. Conversion of the morpholine and pyrrolidine enamines of symmetrical dialkylketones to the corresponding threo-β-amino alcohols via hydroboration/oxidation
  作者：Christian T. Goralski、Dennis L. Hasha、Lawrence W. Nicholson、Donald Zakett、Gary B. Fisher、Bakthan Singaram

  DOI：10.1016/s0040-4039(00)76877-8

  日期：1994.5

  The hydroboration of the morpholine and pyrrolidine enamines of symmetrical dialkylketones with BMS followed by methanolysis and oxidation with basic hydrogen peroxide gave the corresponding threo-β-amino alcohols in moderate yields.

  用BMS对对称二烷基酮的吗啉和吡咯烷烯胺进行氢硼化，然后进行甲醇分解和碱性过氧化氢氧化，以中等收率得到相应的苏-β-氨基醇。
• Hydroboration. 86. Convenient conversion of aldehydes and ketones into the corresponding alkenes via hydroboration of their enamines. A remarkably simple synthesis of either (Z)- or (E)-alkenes
  作者：Bakthan Singaram、Milind V. Rangaishenvi、Herbert C. Brown、Christian T. Goralski、Dennis L. Hasha

  DOI：10.1021/jo00004a038

  日期：1991.2

  Aldehydes and ketones are converted into the corresponding alkenes via hydroboration of their enamines. Hydroboration of aldehyde enamines by 9-borabicyclo[3.3.1]nonane (9-BBN), followed by methanolysis, affords the corresponding terminal alkenes in 75-90% yields. Unsaturated aldehyde enamines produce the corresponding dienes under these conditions. Enamines derived from substituted cyclic ketones and heterocyclic ketones are readily accommodated in this reaction to afford the corresponding alkenes in very good yields. The synthesis of pure (Z)- or (E)-alkenes is readily achieved from the same acyclic ketone enamine by modification of the hydroboration-elimination procedure: (A) hydroboration by 9-BBN followed by methanolysis or (B) hydroboration by borane methyl sulfide (BMS) followed by methanolysis and hydrogen peroxide oxidation. Mechanistic rationale is provided.
• Construction of five-membered rings by Michael addition-radical cyclization
  作者：Derrick L. J. Clive、Taryn L. B. Boivin、A. Gaetan Angoh

  DOI：10.1021/jo00231a021

  日期：1987.10
• SINGARAM, BAKTHAN;RANGAISHENVI, MILIND V.;BROWN, HERBERT C.;GORALSKI, CHR+, J. ORG. CHEM., 56,(1991) N, C. 1543-1549
  作者：SINGARAM, BAKTHAN、RANGAISHENVI, MILIND V.、BROWN, HERBERT C.、GORALSKI, CHR+

  DOI：——

  日期：——
• SUZUKI KUNIO; SEKIYA MINORU, SYNTHESIS, 1981, NO 4, 297-299
  作者：SUZUKI KUNIO、 SEKIYA MINORU

  DOI：——

  日期：——