7-[5-(4-fluoro-benzyl)-thiazol-2-yl]-6-hydroxy-1-[2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-1H-imidazo[1,2-a]pyrimidin-5-one | 1202898-42-7

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 7-[5-(4-fluoro-benzyl)-thiazol-2-yl]-6-hydroxy-1-[2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-1H-imidazo[1,2-a]pyrimidin-5-one
• 英文别名: 7-[5-[(4-Fluorophenyl)methyl]thiazol-2-yl]-6-hydroxy-1-[2-(4-methyl-1-piperidyl)-2-oxo-ethyl]imidazo[1,2-a]pyrimidin-5-one；7-[5-[(4-fluorophenyl)methyl]-1,3-thiazol-2-yl]-6-hydroxy-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]imidazo[1,2-a]pyrimidin-5-one
• CAS: 1202898-42-7
• 化学式: C₂₄H₂₄FN₅O₃S
• 分子量: 481.551
• InChiKey: PCDLRIUITBETIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] IMIDAZOPYRIMIDINONES AND USES THEREOF<br/>[FR] IMIDAZOPYRIMIDINONES ET LEURS UTILISATIONS
  申请人：AVEXA LTD

  公开号：WO2010000031A1

  公开（公告）日：2010-01-07

  The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.

  本发明提供了一种式（I）的化合物或其药用可接受的衍生物、盐或前药。本发明还提供了一种治疗或预防受试者病毒感染的方法，包括向该受试者施用一定剂量的式（I）的化合物或其药用可接受的衍生物、盐或前药。还提供了含有式（I）的化合物的药物组合物。
• IMIDAZOPYRIMIDINES AND USES THEREOF
  申请人：Deadman John Joseph

  公开号：US20110028487A1

  公开（公告）日：2011-02-03

  The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.

  本发明提供了式（I）化合物或其药学上可接受的衍生物、盐或前药。本发明还提供了一种治疗或预防受体内病毒感染的方法，包括向该受体内注射有效量的式（I）化合物或其药学上可接受的衍生物、盐或前药。还提供了包括式（I）化合物的制药组合物。
• IMIDAZOPYRIMIDINONES AND USES THEREOF
  申请人：Avexa Limited

  公开号：EP2291377A1

  公开（公告）日：2011-03-09
• US8431581B2
  申请人：——

  公开号：US8431581B2

  公开（公告）日：2013-04-30