2-{(3S)-3-[(tert-Butoxycarbonyl)amino]pyrrolidinyl}-3-(1H-imidazol-4-yl)propanoic Acid | 607376-94-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-{(3S)-3-[(tert-Butoxycarbonyl)amino]pyrrolidinyl}-3-(1H-imidazol-4-yl)propanoic Acid
• 英文别名: 3-(1H-imidazol-5-yl)-2-[(3S)-3-[(2-methylpropan-2-yl)oxycarbonylamino]pyrrolidin-1-yl]propanoic acid
• CAS: 607376-94-3
• 化学式: C₁₅H₂₄N₄O₄
• 分子量: 324.38
• InChiKey: RRCUDXRANHUSJX-NUHJPDEHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• 3-(Imidazolyl)-2-aminopropanoic acids
  申请人：Pfizer Inc.

  公开号：US20030191107A1

  公开（公告）日：2003-10-09

  Compounds according to formula (I) wherein n is 1-4, R 1 is optionally substituted C 1-6 alkyl, C 2-6 alkenyl, or C 2-6 alkynyl, Heterocycle, Aromatic heterocycle, Aryl or hydrogen and R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are each independently selected from hydrogen and optionally substituted C 1-6 alkyl are novel. They are useful in the treatment of thrombotic conditions and other pathologies associated with fibrin deposition. 1

  根据公式(I)，其中n为1-4，R1是可选取代的C1-6烷基、C2-6烯基或C2-6炔基、杂环、芳香杂环、芳基或氢，而R2、R3、R4、R5、R6、R7和R8各自独立选择自氢和可选取代的C1-6烷基的化合物是新颖的。它们在治疗血栓症和与纤维蛋白沉积相关的其他病理情况中非常有用。
• 3-(imidazolyl)-2-aminopropanoic acids
  申请人：Pfizer Inc

  公开号：US20040192668A1

  公开（公告）日：2004-09-30

  Compounds according to formula (I) wherein n is 1-4, R 1 is optionally substituted C 1-6 alkyl, C 2-6 alkenyl, or C 2-6 alkynyl, Heterocycle, Aromatic heterocycle, Aryl or hydrogen and R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are each independently selected from hydrogen and optionally substituted C 1-6 alkyl are novel. They are useful in the treatment of thrombotic conditions and other pathologies associated with fibrin deposition. 1

  公式（I）中的化合物，其中n为1-4，R1为可选取代的C1-6烷基，C2-6烯基或C2-6炔基，杂环，芳香杂环，芳基或氢，而R2，R3，R4，R5，R6，R7和R8各自独立地选自氢和可选取代的C1-6烷基，是新颖的。它们在治疗血栓性疾病和与纤维蛋白沉积有关的其他病理情况中有用。
• US6759426B2
  申请人：——

  公开号：US6759426B2

  公开（公告）日：2004-07-06
• US6919457B2
  申请人：——

  公开号：US6919457B2

  公开（公告）日：2005-07-19
• [EN] 3-(IMIDAZOLYL)-2-AMINOPROPANOIC ACIDS FOR USE AS TAFI-A INHIBITORS FOR THE TREATMENT OF THROMBOTIC DISEASES<br/>[FR] ACIDES 3-(IMIDAZOLYL)-2-AMINOPROPANOIQUES SERVANT D'INHIBITEURS TAFIA POUR TRAITER DES MALADIES THROMBOTIQUES
  申请人：PFIZER LTD

  公开号：WO2003061653A1

  公开（公告）日：2003-07-31

  Compounds according to formula (I) wherein n is 1-4, R1 is optionally substituted C1-6alkyl, C2-6alkenyl, or C2-6alkynyl, Heterocycle, Aromatic heterocycle, Aryl or hydrogen and R2, R3, R4, R5, R6, R7 and R8 are each independently selected from hydrogen and optionally substituted C1-6 alkyl are novel. They are useful in the treatment of thrombotic conditions and other pathologies associated with fibrin deposition. (1).