1-(o,p-Dimethylphenyl)-pyrrol-2-carbonsaeure | 37560-60-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-(o,p-Dimethylphenyl)-pyrrol-2-carbonsaeure
• 英文别名: 1-(2,4-Dimethylphenyl)pyrrole-2-carboxylic acid
• CAS: 37560-60-4
• 化学式: C₁₃H₁₃NO₂
• 分子量: 215.252
• InChiKey: CICINEYBXDFBRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• CYCLIC COMPOUNDS
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1732541A2

  公开（公告）日：2006-12-20
• EP1732541A4
  申请人：——

  公开号：EP1732541A4

  公开（公告）日：2008-03-05
• [EN] CYCLIC COMPOUNDS<br/>[FR] COMPOSES CYCLIQUES
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2005099688A2

  公开（公告）日：2005-10-27

  There is provided a CRF receptor antagonist comprising a compound of the formula (I): A-W-Ar wherein, A is a group represented by the formula (A1) or (A2) (wherein, ring Aa is a 5-or 6-membered ring which may be further substituted; ring Ab is a 5-or 6-membered ring which may be further substituted; ring Ac is a 5- or 6-membered ring which may be substituted; R1 is optionally substituted alkyl, substituted amino, substituted hydroxy, etc.; X is carbonyl, -O-, -S-, etc.; Y1, Y2 and Q are independently optionally substituted carbon or nitrogen; … is a single or double bond); W is a bond, optionally substituted methylene, optionally substituted imino, -O-, -S-, etc.; Ar is optionally substituted aryl or optionally substituted heteroaryl; or a salt thereof or a prodrug thereof.