1,1,1-trifluoro-3-(1-methylindan-1-yl)propan-2-one | 1055934-98-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 1,1,1-trifluoro-3-(1-methylindan-1-yl)propan-2-one
• 英文别名: 1,1,1-Trifluoro-3-(1-methyl-2,3-dihydroinden-1-yl)propan-2-one
• CAS: 1055934-98-9
• 化学式: C₁₃H₁₃F₃O
• 分子量: 242.241
• InChiKey: BTFJRENKTFTUSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] 1-PROPANOL AND 1-PROPYLAMINE DERIVATIVES AND THEIR USE AS GLUCOCORTICOID LIGANDS<br/>[FR] DERIVES DE 1-PROPANOL ET 1-PROPYLAMINE ET LEUR UTILISATION EN TANT QUE LIGANDS DE GLUCOCORTICOIDE
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2004063163A1

  公开（公告）日：2004-07-29

  Compounds of Formula (I) wherein R1, R2 R3, R4, R5, R6, and X are as defiend herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocoricoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

  式(I)的化合物，其中R1、R2、R3、R4、R5、R6和X如式(IA)和式(IB)中所定义，或其异构体、前药、溶剂化合物或盐；含有这些化合物的药物组合物，以及使用这些化合物调节糖皮质激素受体功能的方法，以及使用这些化合物治疗由糖皮质激素受体功能介导或以炎症、过敏或增殖过程为特征的疾病状态或病况的方法。
• Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
  申请人：Kirrane Martin Thomas

  公开号：US20050203128A1

  公开（公告）日：2005-09-15

  Compounds of Formula (IA) and Formula (IB) where in R 1 stands for the following group (the dashed line indicates the point of attachment) and R 2 , R 3 , R 4 , R 5 , R 6 , Y, Z, X 1 and X 2 are as defined herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

  化合物的化学式（IA）和化学式（IB），其中R1代表以下基团（虚线表示连接点），而R2、R3、R4、R5、R6、Y、Z、X1和X2如本文所定义的化学式（IA）和化学式（IB）中的定义，或其异构体、前药、溶剂化合物或盐；包含这类化合物的药物组合物，以及使用这些化合物调节糖皮质激素受体功能的方法，以及使用这些化合物治疗由糖皮质激素受体功能介导或以炎症、过敏或增殖过程为特征的疾病状态或病情的方法。
• Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：US20040162321A1

  公开（公告）日：2004-08-19

  Compounds of Formula (I) 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and X are as defined herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof, pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

  该化合物的公式(I)1，其中R1，R2，R3，R4，R5，R6和X的定义如公式(IA)和公式(IB)中所述，或其互变异构体、前药、溶剂化物或盐，制备含有该化合物的药物组合物，并使用这些化合物调节糖皮质激素受体功能的方法以及治疗由糖皮质激素受体功能介导或以炎症、过敏或增生过程为特征的疾病状态或病情的方法。
• 1-PROPANOL AND 1-PROPYLAMINE DERIVATIVES AND THEIR USE AS GLUCOCORTICOID LIGANDS
  申请人：Boehringer Ingelheim Pharmaceuticals Inc.

  公开号：EP1583745A1

  公开（公告）日：2005-10-12
• 2-PROPANOL AND 2-PROPYLAMINE DERIVATIVES AND THEIR USE AS GLUCOCORTICOID LIGANDS
  申请人：Boehringer Ingelheim Pharmaceuticals Inc.

  公开号：EP1727813A1

  公开（公告）日：2006-12-06