4-(2,3-二甲基马来酰亚胺基)马尿酸 | 83560-86-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(2,3-二甲基马来酰亚胺基)马尿酸
• 中文别名: 吡啶并[3',4':4,5]呋喃并[2,3-b]吡啶,5-乙氧基-
• 英文名称: N-(2,3-dimethylmaleimido) hippuric acid
• 英文别名: 4-(2,3-dimethylmaleimido)hippuric acid；2-[[4-(3,4-dimethyl-2,5-dioxopyrrol-1-yl)benzoyl]amino]acetic acid
• CAS: 83560-86-5
• 化学式: C₁₅H₁₄N₂O₅
• 分子量: 302.287
• InChiKey: IYZVVULPBGFSRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2925190090

反应信息

• 作为产物：
  描述：

  对氨基马尿酸 在 溶剂黄146 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 3.5h， 生成 4-(2,3-二甲基马来酰亚胺基)马尿酸
  参考文献：
  名称：

  Acute effects of alkylating agents on canine renal function: specifically designed synthetic maleimides

  摘要：

  Maleimidohippurates and maleimidobenzoates were synthesized that possess a carboxy group for active uptake into renal proximal tubular cells and a reactive maleimide moiety to covalently bond with proximal tubular components. The reactivity of the maleimide moiety in each series was progressively reduced by substitution of methyl groups in place of the vinyl hydrogens. In contrast to N-ethylmaleimide (NEM), the resulting maleimidohippurates and maleimidobenzoates did not possess significant diuretic activity in the dog following renal arterial administration. However, as predicted, the nephrotoxicity of the maleimidohippurates paralleled their in vitro alkylating ability and was quite specifically located in the proximal portion of the canine renal tubule.

  DOI：

  10.1021/jm00355a017

文献信息

• Fles, Dragutin; Vukovic, Radivoje; Kuzmic, Ana Erceg, Croatica Chemica Acta, 2003, vol. 76, # 1, p. 69 - 74
  作者：Fles, Dragutin、Vukovic, Radivoje、Kuzmic, Ana Erceg、Bogdanic, Grozdana、Pilizota, Vlasta、Karlovic, Damir、Markus, Kresimir、Wolsperger, Kristina、Vikic-Topic, Drazen

  DOI：——

  日期：——