3-[4-(3-methoxy-pyridin-4-yl)-5-methyl-pyrimidin-2-ylamino]-benzenesulfonamide | 1035943-73-7

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 3-[4-(3-methoxy-pyridin-4-yl)-5-methyl-pyrimidin-2-ylamino]-benzenesulfonamide
• 英文别名: 3-[[4-(3-Methoxypyridin-4-yl)-5-methylpyrimidin-2-yl]amino]benzenesulfonamide
• CAS: 1035943-73-7
• 化学式: C₁₇H₁₇N₅O₃S
• 分子量: 371.42
• InChiKey: YUONOKPVLBLHNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Organic Compounds and Their Uses
  申请人：Beckwith Rohan Eric John

  公开号：US20100048597A1

  公开（公告）日：2010-02-25

  The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.

  本申请描述了有机化合物，可用于治疗、预防和/或缓解疾病。
• HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS
  申请人：Sharpless Norman E.

  公开号：US20110224227A1

  公开（公告）日：2011-09-15

  Methods for reducing or preventing the effects of cytotoxic compounds in healthy cells are provided. The methods relate to the use of selective cyclin-dependent kinase (CDK) 4/6 inhibitors to induce transient quiescence in CDK4/6 dependent cells, such as hematopoietic stem cells and/or hematopoietic progenitor cells. Also described is a method of selecting compounds for reducing or preventing the effects of cytotoxic agents compounds in healthy cells.
• HEMATOPOIETIC PROTECTION AGAINST IONIZING RADIATION USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS
  申请人：Sharpless Norman E.

  公开号：US20110224221A1

  公开（公告）日：2011-09-15

  Methods for reducing or preventing the effects of ionizing radiation in healthy cells arc provided. The methods relate to the use of selective cyclin-dependent kinase (CDK) 4/6 inhibitors to induce transient quiescence in CDK4/6 dependent cells, such as hematopoietic stem cells and/or hematopoietic progenitor cells. Radioprotection can be effected in mammals by treatment with selective CDK4/6 inhibitor compounds either before, at the same time as, or after exposure to the ionizing radiation.