2-(3,3-Dimethyl-ureido)-4-(pyridin-3-ylmethylsulfanyl)-thiophene-3-carboxylic acid amide | 309278-83-9

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 2-(3,3-Dimethyl-ureido)-4-(pyridin-3-ylmethylsulfanyl)-thiophene-3-carboxylic acid amide
• 英文别名: 2-(Dimethylcarbamoylamino)-4-(pyridin-3-ylmethylsulfanyl)thiophene-3-carboxamide
• CAS: 309278-83-9
• 化学式: C₁₄H₁₆N₄O₂S₂
• 分子量: 336.439
• InChiKey: CXKKXCQHZAHPHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  142
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• HETEROCYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS
  申请人：Pfizer Products Inc.

  公开号：EP1187826A1

  公开（公告）日：2002-03-20
• US6380214B1
  申请人：——

  公开号：US6380214B1

  公开（公告）日：2002-04-30
• [EN] HETEROCYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS<br/>[FR] DERIVES HETEROCYCLIQUES SERVANT D'AGENTS ANTICANCEREUX
  申请人：PFIZER PROD INC

  公开号：WO2000071532A1

  公开（公告）日：2000-11-30

  The present invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein Z, X, X?1, R1, R2 and R3¿ are as defined herein as it relates to pharmaceutical compositions containing the above compounds for the treatment of disorders mediated by angiogenesis in mammals by administration of the above compounds.