N-cyclohexyl-4-(2-fluorobenzyl)morpholine-2-carboxyamide | 1401231-05-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-cyclohexyl-4-(2-fluorobenzyl)morpholine-2-carboxyamide
• 英文别名: N-cyclohexyl-4-[(2-fluorophenyl)methyl]morpholine-2-carboxamide
• CAS: 1401231-05-7
• 化学式: C₁₈H₂₅FN₂O₂
• 分子量: 320.407
• InChiKey: XEGDELLWHSRDFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] A COMPOUND FOR INHIBITING HUMAN 11-ß-HYDROXY STEROID DEHYDROGENASE TYPE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME<br/>[FR] COMPOSÉ CAPABLE D'INHIBER LA 11-BÊTA-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE DE TYPE 1 HUMAINE ET COMPOSITION PHARMACEUTIQUE EN CONTENANT
  申请人：HYUNDAI PHARM CO LTD

  公开号：WO2012128582A2

  公开（公告）日：2012-09-27

  The present invention relates to a novel compound, or a stereoisomer, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) comprising the same. The invention provides a compound, which has excellent activity and solubility and is more efficiently formulated and delivered, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 comprising the same.