4-Methoxy-4-methylpentanoic acid | 1056595-79-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-Methoxy-4-methylpentanoic acid
• CAS: 1056595-79-9
• 化学式: C₇H₁₄O₃
• 分子量: 146.18
• InChiKey: OWCBXMDQEWVPLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Palani Anandan

  公开号：US20080019978A1

  公开（公告）日：2008-01-24

  The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, esters, and tautomers thereof, wherein: Q is selected from the group consisting of: and L is selected from the group consisting of: pharmaceutically compositions comprising one or more compounds of formula (I), and methods of using the compounds of formula (I).

  本发明提供了式（I）的化合物及其药学上可接受的盐，溶剂化合物，酯和互变异构体，其中： Q选自以下组： L选自以下组： 本发明还提供了包含一种或多种式（I）化合物的药学组合物以及使用式（I）化合物的方法。
• Nitrogen-containing heterocyclic compounds and methods of use thereof
  申请人：Palani Anandan

  公开号：US20070066630A1

  公开（公告）日：2007-03-22

  The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, esters, and tautomers thereof, wherein: Q is selected from the group consisting of: L is selected from the group consisting of: pharmaceutically compositions comprising one or more compounds of formula (I), and methods of using the compounds of formula (I).

  本发明提供了式（I）化合物及其药学上可接受的盐、溶剂化合物、酯和互变异构体，其中：Q选自以下组：L选自以下组：包括一种或多种式（I）化合物的药学组合物，以及使用式（I）化合物的方法。
• 3- (4-{ [4- (4-{ [3-(3, 3-Dimethyl-1-Piperidinyl) Propyl] Oxy} Phenyl) -1-Piperidinyl] Carbonyl}-1-Naphthalenyl) Propanoic or Propenoic Acid as H1 and H3 Receptor Antagonists for the Treatment of Inflammatory and/or Allergic Disorders
  申请人：Hodgson Simon Teanby

  公开号：US20080312280A1

  公开（公告）日：2008-12-18

  The present invention relates to a compound of formula (I), or a salt thereof wherein the naphthalene ring is substituted in the 2, 3, 4, 5, 6, 7 or 8 position by R 1 , and R 1 represents —CH 2 CH 2 COOH or —CH═C(CH 3 )COOH, and to processes for their preparation, to compositions containing them and to their use in the treatment of various inflammatory and/or allergic diseases, such as diseases such as allergic rhinitis.

  本发明涉及一种式（I）的化合物或其盐，其中萘环在2、3、4、5、6、7或8位被R1取代，R1代表—CH2CH2COOH或—CH═C(CH3)COOH，以及它们的制备方法、含有它们的组合物以及它们在治疗各种炎症和/或过敏性疾病（如过敏性鼻炎等疾病）中的用途。
• 3-(4-{[4-(4-{[3-(3,3-DIMETHYL-1-PIPERIDINYL)PROPYL]OXY}PHENYL)-1-PIPERIDINYL]CARBONYL}-1-NAPHTHALENYL)PROPANOIC OR PROPENOIC ACID AS H1 AND H3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY AND/OR ALLERGIC DISORDERS
  申请人：GLAXO GROUP LIMITED

  公开号：EP2157087A1

  公开（公告）日：2010-02-24

  The present invention relates to the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof wherein the naphthalene ring can be substituted in the 2, 3, 4, 5, 6, 7 or 8 position by R1, and R1 represents -CH2CH2COOH or -CH=C(CH3)COOH, in the treatment of various diseases such as nephritis, skin diseases or hypersensitivity reactions.

  本发明涉及式（I）化合物或其药学上可接受的盐的用途 其中萘环可在 2、3、4、5、6、7 或 8 位被 R1 取代，且 R1 代表 -CH2CH2COOH 或 -CH=C(CH3)COOH，用于治疗各种疾病，如肾炎、皮肤病或超敏反应。
• US7723342B2
  申请人：——

  公开号：US7723342B2

  公开（公告）日：2010-05-25