4,5,5-Trimethylpiperazin-2-one | 1849330-59-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4,5,5-Trimethylpiperazin-2-one
• CAS: 1849330-59-1
• 化学式: C₇H₁₄N₂O
• 分子量: 142.2
• InChiKey: UZBULTJEXKWSRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：US20180057505A1

  公开（公告）日：2018-03-01

  The compounds of formula I, wherein the variables are as defined herein, and pharmaceutically acceptable salts thereof are useful as inhibitors of the PAR-2 signaling pathway. The compounds of formula I and pharmaceutically acceptable compositions comprising such compounds can be employed for treating various diseases, disorders, and conditions.