N-cyclohexyl-3,4-dihydro-8-methoxy-2-oxo-2H-chromene-4-carboxamide | 1158433-74-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: N-cyclohexyl-3,4-dihydro-8-methoxy-2-oxo-2H-chromene-4-carboxamide
• 英文别名: N-cyclohexyl-8-methoxy-2-oxo-3,4-dihydrochromene-4-carboxamide
• CAS: 1158433-74-9
• 化学式: C₁₇H₂₁NO₄
• 分子量: 303.358
• InChiKey: FPUUNKUOMMXQJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丙二酸环(亚)异丙酯 、 异氰环已烷 、 邻香草醛 以 二氯甲烷 为溶剂， 生成 N-cyclohexyl-3,4-dihydro-8-methoxy-2-oxo-2H-chromene-4-carboxamide
  参考文献：
  名称：

  Synthesis and Biological Evaluation of Coumarin Derivatives as Inhibitors ofMycobacterium bovis(BCG)

  摘要：

  The coumarin compounds are an important class of biologically active molecules, which have attractive caught the attention of many organic and medicinal chemists, due to potential pharmaceutical implications and industrial applications. We herein report the one‐pot procedure for the efficient synthesis of coumarin derivatives using commercially available substrates via isocyanide‐based multicomponent condensation reactions. These compounds were evaluated for anti‐mycobacterium activity against Mycobacterium bovis (Bacillus Calmette–Guerin). The preliminary results indicated that all of the tested compounds showed relatively good activity against the test organism. The compounds 7e, 7l, and 7m showed high anti‐tuberculosis activity.

  DOI：

  10.1111/cbdd.12044