(S)-4-(4-(3-(3-chlorophenethylamino)-3-oxo-2-(3-(pyridin-3-yl)propanamido)propyl)phenoxy)butanoic acid | 1196833-45-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-4-(4-(3-(3-chlorophenethylamino)-3-oxo-2-(3-(pyridin-3-yl)propanamido)propyl)phenoxy)butanoic acid
• 英文别名: 4-[4-[(2S)-3-[2-(3-chlorophenyl)ethylamino]-3-oxo-2-(3-pyridin-3-ylpropanoylamino)propyl]phenoxy]butanoic acid
• CAS: 1196833-45-0
• 化学式: C₂₉H₃₂ClN₃O₅
• 分子量: 538.043
• InChiKey: TZULHVDPZYXEEF-SANMLTNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  38
• 可旋转键数：
  15
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  在 lithium hydroxide 作用下， 生成 (S)-4-(4-(3-(3-chlorophenethylamino)-3-oxo-2-(3-(pyridin-3-yl)propanamido)propyl)phenoxy)butanoic acid
  参考文献：
  名称：

  基于小分子的结合环境：用于多重亲和筛选的微阵列的组合构建

  摘要：

  本文介绍了组合人工受体阵列 (CARA) 的构建以及该阵列在基于其结合模式的蛋白质分化中的应用。显示 5035 个独特结合环境的微阵列是使用 19 个小分子构建块的库制备的。每个构建块都配备了一个羧酸手柄，允许构建块的混合物被点在胺官能化的载玻片的表面上，以作为结合环境的亚基进行共价固定。该策略采用微阵列表面作为受体合成平台，从而实现阵列制备的灵活性和应用的敏捷性。CARA 策略的一个优势是它在构建替代微阵列配置方面具有巨大的灵活性，这有助于快速访问绑定空间的广度和深度。四种荧光标记的蛋白质、泛素、肌红蛋白、α-1-酸性糖蛋白和溶菌酶与阵列一起孵育，以证明结合的重现性和可以实现的分化水平。绑定环境稳定、可扩展，并适用于其他格式。

  DOI：

  10.1021/ja9046944

文献信息

• FILTRATION ARTICLE WITH MICROBIAL REMOVAL, MICRO-BIOCIDAL, OR STATIC GROWTH CAPABILITY
  申请人：Carlson Robert E.

  公开号：US20120241391A1

  公开（公告）日：2012-09-27

  Disclosed are filter media constituents, filter media, filter constructions, and methods of employing the filter media and filter constructions for fluid filtration. The filter media and filter media constituents of the invention have unique properties enabling the efficient capture of microbes or microbial generating units. Fluids usefully filtered using the filter media and filter constructions include air and water.
• FIBER WITH MICROBIAL REMOVAL, MICRO-BIOCIDAL, OR STATIC GROWTH CAPABILITY
  申请人：Carlson Robert E.

  公开号：US20120263771A1

  公开（公告）日：2012-10-18

  The fiber structures in the form of a fiber (or fiber mass), woven or nonwoven fabric, fiber absorbent layers, mats or bats or other collection of fiber can be modified to be microbiocidal, bacteriostatic, obtain immobilized, microbes, etc. The disclosed fiber has the unique ability to capture and hold microbes or microbial generating units within the fiber mass.
• [EN] FIBER WITH MICROBIAL REMOVAL, MICRO-BIOCIDAL, OR STATIC GROWTH CAPABILITY<br/>[FR] FIBRE CAPABLE D'ÉLIMINER LES MICROBES, À ACTION MICROBICIDE OU À CROISSANCE STATIQUE
  申请人：RECEPTORS LLC

  公开号：WO2012135034A1

  公开（公告）日：2012-10-04

  The fiber structures in the form of a fiber (or fiber mass), woven or nonwoven fabric, fiber absorbent layers, mats or bats or other collection of fiber can be modified to be microbiocidal, bacteriostatic, obtain immobilized microbes, etc. The disclosed fiber has the unique ability to capture and hold microbes or microbial generating units within the fiber mass.
• [EN] FILTRATION ARTICLE WITH MICROBIAL REMOVAL, MICRO-BIOCIDAL, OR STATIC GROWTH CAPABILITY<br/>[FR] ARTICLE DE FILTRATION AVEC ÉLIMINATION DES MICROBES, ACTIVITÉ MICROBICIDE OU CAPACITÉ DE CROISSANCE STATIQUE
  申请人：RECEPTORS LLC

  公开号：WO2012135042A1

  公开（公告）日：2012-10-04

  Disclosed are filter media constituents, filter media, filter constructions, and methods of employing the filter media and filter constructions for fluid filtration. The filter media and filter media constituents of the invention have unique properties enabling the efficient capture of microbes or microbial generating units. Fluids usefully filtered using the filter media and filter constructions include air and water.