2-acetoxy-3-phenylpropenoic acid | 21027-12-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-acetoxy-3-phenylpropenoic acid
• 英文别名: α-Acetoxyzimtsaeure；(Z)-2-acetyloxy-3-phenylprop-2-enoic acid
• CAS: 21027-12-3
• 化学式: C₁₁H₁₀O₄
• 分子量: 206.198
• InChiKey: MSFXPXIVPZXOKN-YFHOEESVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-脒-2-萘酚 甲基磺酸 、 2-acetoxy-3-phenylpropenoic acid 、 甲烷磺酸 、 N,N'-二环己基碳二亚胺 以18%的产率得到
  参考文献：
  名称：

  AOYAMA, TAKUO;OKUTOME, TOSHIYUKI;NAKAYAMA, TOYOO;YAEGASHI, TAKASHI;MATSUI+, CHEM. AND PHARM. BULL., 1985, 33, N 4, 1458-1471

  摘要：

  DOI：
• 作为产物：
  描述：

  (Z)-4-亚苄基-2-甲基噁唑-5(4h)-酮 在 溶剂黄146 作用下， 生成 2-acetoxy-3-phenylpropenoic acid
  参考文献：
  名称：

  PHENYLPYRUVIC ACID DERIVATIVES AS ENZYME INHIBITORS: THERAPEUTIC POTENTIAL ON MACROPHAGE MIGRATION INHIBITORY FACTOR

  摘要：

  Phenylpyruvic acid derivatives are obtained by hydrolysing aromatic Z/E azlactones. Keto tautomers interact with enzyme systems such as phenylalanine dehydrogenase or carboxypeptidase A whereas enol tautomers are potential inhibitors on the phenylpyruvate tautomerase activity catalysed by Macrophage Migration Inhibitory Factor (MIF). MIF being a key molecule in immune and inflammatory processes several structures with reasonable interaction with MIF and protocol for specific synthesis are presented.

  DOI：

  10.1007/s00044-004-0102-y

文献信息

• Compositions and methods to co-localize luminophores with luminescent proteins
  申请人：——

  公开号：US20030153090A1

  公开（公告）日：2003-08-14

  A method of measuring the enzymatic activity of a luciferase includes contacting a luminogenic protein, such as a luciferase, with a protected luminophore to form a composition; and detecting light produced from the composition. The protected luminophore provides increased stability and improved signal-to-background ratios relative to the corresponding unmodified coelenterazine.

  一种测量荧光酶活性的方法包括将荧光蛋白（如荧光酶）与保护性荧光物质接触以形成一种组合物；并检测组合物产生的光。相对于相应的未经修改的海葵蓝素，保护性荧光物质提供了更高的稳定性和改善的信号背景比率。
• COMPOSITIONS AND METHODS TO CO-LOCALIZE LUMINOPHORES WITH LUMINESCENT PROTEINS
  申请人：Wood Keith

  公开号：US20080050760A1

  公开（公告）日：2008-02-28

  A method of measuring the enzymatic activity of a luciferase includes contacting a luminogenic protein, such as a luciferase, with a protected luminophore to form a composition; and detecting light produced from the composition. The protected luminophore provides increased stability and improved signal-to-background ratios relative to the corresponding unmodified coelenterazine.

  一种测量荧光素酶酶活性的方法包括将荧光素酶等发光蛋白与受保护的发光物质接触，形成一种组合物；并检测组合物产生的光。受保护的发光物质相对于相应未修饰的海葵蓝素提供了更高的稳定性和改善的信号与背景比率。
• COMPOSITIONS, METHODS AND KITS PERTAINING TO LUMINESCENT COMPOUNDS
  申请人：PROMEGA CORPORATION

  公开号：EP1451155A1

  公开（公告）日：2004-09-01
• EP1451155A4
  申请人：——

  公开号：EP1451155A4

  公开（公告）日：2006-03-01
• EP1451155B1
  申请人：——

  公开号：EP1451155B1

  公开（公告）日：2008-07-02