N-[N-(4-nitro-benzoyl)-glycyl]-leucine methyl ester | 84742-47-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[N-(4-nitro-benzoyl)-glycyl]-leucine methyl ester
• 英文别名: N-[N-(4-Nitro-benzoyl)-glycyl]-leucin-methylester
• CAS: 84742-47-2
• 化学式: C₁₆H₂₁N₃O₆
• 分子量: 351.359
• InChiKey: CEDYNMKEGGBUHR-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  重氮甲烷 、 alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 作用下， 生成 N-[N-(4-nitro-benzoyl)-glycyl]-leucine methyl ester
  参考文献：
  名称：

  Plasma atrial natriuretic peptide levels in essential hypertension after treatment with verapamil

  摘要：

  The aim of this study was to evaluate the long term effects of the selective Ca2+ blocker verapamil on atrial natriuretic peptide (ANP) levels in patients with moderate essential hypertension. The drug was given orally in a daily dose of 300 mg for 30 days. At the end of this clinical trial, plasma ANP levels increased by 16.14% despite the drop in blood pressure while left atrial and ventricular diameters remained unchanged. These findings indicate that the increase of ANP plasma levels is not the result of a mechanical load on the left cardiac chambers but the result of a pharmacological action. These observations also indicate that verapamil exerts part of its antihypertensive action by increasing ANP plasma levels.

  DOI：

  10.1007/bf03190404