2-Methyl-2-[2-(4-methylphenyl)sulfonyl-4-phenylbutyl]-1,3-dioxolane | 106369-12-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Methyl-2-[2-(4-methylphenyl)sulfonyl-4-phenylbutyl]-1,3-dioxolane
• CAS: 106369-12-4
• 化学式: C₂₁H₂₆O₄S
• 分子量: 374.501
• InChiKey: YEAAWWSLDBWZEK-UHFFFAOYSA-N

物化性质

• 沸点：
  537.3±50.0 °C(Predicted)
• 密度：
  1.158±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  61
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Methyl-2-[2-(4-methylphenyl)sulfonyl-4-phenylbutyl]-1,3-dioxolane 在 叔丁基锂 、 臭氧 作用下， 生成 3-(2-Methyl-[1,3]dioxolan-2-ylmethyl)-5-phenyl-3-(toluene-4-sulfonyl)-pentanal
  参考文献：
  名称：

  Synthesis of 3-alkyl-5-hydroxycyclohex-2-enones via aldolic addition/sulfinate elimination tandem reactions

  摘要：

  The first synthesis of 3-alkyl-5-hydroxycyclohex-2-enones is reported. An intramolecular cyclization by means of an aldolic addition/sulfinate elimination tandem reactions, performed under mild basic conditions was the key step. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01085-2
• 作为产物：
  描述：

  2-methyl-2-[2-(toluene-4-sulfonyl)-ethyl]-[1,3]dioxolane 、 alkaline earth salt of/the/ methylsulfuric acid 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 以60%的产率得到2-Methyl-2-[2-(4-methylphenyl)sulfonyl-4-phenylbutyl]-1,3-dioxolane
  参考文献：
  名称：

  Synthesis of 3-alkyl-5-hydroxycyclohex-2-enones via aldolic addition/sulfinate elimination tandem reactions

  摘要：

  The first synthesis of 3-alkyl-5-hydroxycyclohex-2-enones is reported. An intramolecular cyclization by means of an aldolic addition/sulfinate elimination tandem reactions, performed under mild basic conditions was the key step. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01085-2

文献信息

• A NEW AND EFFECTIVE AMINOMETHYLATION BY THE USE OF<i>N</i>-(<i>p</i>-TOLUENESULFONYLMETHYL)-<i>p</i>-TOLUENESULFONAMIDE AS AN EQUIVALENT OF METHANIMINE. A CONVENIENT PREPARATION OF PYRROLE COMPOUNDS
  作者：Hideki Kinoshita、Katsuhiko Inomata、Masatoshi Hayashi、Takeshi Kondoh、Hiroshi Kotake

  DOI：10.1246/cl.1986.1033

  日期：1986.6.5

  N-(p-toluenesulfonylmethyl)-p-toluenesulfonamide was treated with base to generate N-methylene-p-toluenesulfonamide which reacted with a variety of nucleophiles forming the corresponding N-tosyl-aminomethylated compounds in good yields. Furthermore, the N-tosyl-aminomethylated acetals thus obtained were converted into the corresponding N-tosylpyrroles with the aid of acid catalyst in excellent yields.

  容易获得的 N-(对甲苯磺酰基甲基)-对甲苯磺酰胺用碱处理以生成 N-亚甲基-对甲苯磺酰胺，其与多种亲核试剂反应以良好的产率形成相应的 N-甲苯磺酰基-氨基甲基化化合物。此外，由此获得的N-甲苯磺酰基-氨基甲基化缩醛在酸催化剂的帮助下以优异的产率转化为相应的N-甲苯磺酰基吡咯。
• Synthesis of (+)-7-ethyl-5-methyl-6,8-dioxabicyclo(3.2.1)oct-3-ene, an optically active form of the house mouse pheromone.
  作者：Yukio Masaki、Ikuhiro Iwata、Toshihiro Imaeda、Hirohisa Oda、Hiromu Nagashima

  DOI：10.1248/cpb.36.1241

  日期：——

  (+)-(1S, 5R, 7S)-7-Ethyl-5-methyl-6, 8-dioxabicyclo[3. 2. 1]oct-3-ene, an optically active form of the androgen-dependent pheromone of the adult male house mouse (Mus)___ (musculus)___, was synthesized from (+)-(R, R)-diethyl tartrate (via)___ highly site-selective olefination of the 6, 8-dioxabicyclo[3. 2. 1]octane intermediate.

  (+)-(1S, 5R, 7S)-7-Ethyl-5-methyl-6, 8-dioxabicyclo[3.从(+)-(R, R)-酒石酸二乙酯（通过）____6, 8-二氧杂环[3. 2. 1]辛烷中间体的高度定点选择性烯化合成了成年雄性家鼠（Mus）____（musculus）____的雄激素依赖性信息素的光学活性形式--(+)-(1S, 5R, 7S) -7-Ethyl-5-methyl-6, 8-dioxabicyclo[3.
• KINOSHITA HIDEKI; INOMATA KATSUHIKO; HAYASHI MASATOSHI; KONDOH TAKESHI; K+, CHEM. LETT.,(1986) N 6, 1033-1036
  作者：KINOSHITA HIDEKI、 INOMATA KATSUHIKO、 HAYASHI MASATOSHI、 KONDOH TAKESHI、 K+

  DOI：——

  日期：——