(2S)-2,6-diamino-N-[(1R)-1-(2-chlorophenyl)-2-oxocyclohex-3-en-1-yl]hexanamide | 1430202-53-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2,6-diamino-N-[(1R)-1-(2-chlorophenyl)-2-oxocyclohex-3-en-1-yl]hexanamide
• CAS: 1430202-53-1
• 化学式: C₁₈H₂₄ClN₃O₂
• 分子量: 349.86
• InChiKey: WSHPLDIRKMTBSO-MAUKXSAKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  98.2
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• THE USE OF (2R, 6R)-HYDROXYNORKETAMINE, (S)-DEHYDRONORKETAMINE AND OTHER STEREOISOMERIC DEHYDRO AND HYDROXYLATED METABOLITES OF (R,S)- KETAMINE IN THE TREATMENT OF DEPRESSION AND NEUROPATHIC PAIN
  申请人：The United State of America, as Represented by the Secretary, Department od Health and Human Service

  公开号：US20140296241A1

  公开（公告）日：2014-10-02

  The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain disorder (CRPS) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment.
• US9650352B2
  申请人：——

  公开号：US9650352B2

  公开（公告）日：2017-05-16