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2-(3-Chloro-5-nitropyridin-2-yl)acetic acid | 1694868-90-0

中文名称
——
中文别名
——
英文名称
2-(3-Chloro-5-nitropyridin-2-yl)acetic acid
英文别名
2-(3-chloro-5-nitropyridin-2-yl)acetic acid
2-(3-Chloro-5-nitropyridin-2-yl)acetic acid化学式
CAS
1694868-90-0
化学式
C7H5ClN2O4
mdl
——
分子量
216.58
InChiKey
GMNRGJALAPZARM-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    0.8
  • 重原子数:
    14
  • 可旋转键数:
    2
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.14
  • 拓扑面积:
    96
  • 氢给体数:
    1
  • 氢受体数:
    5

文献信息

  • FURO- AND THIENO-PYRIDINE CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
    申请人:Incyte Corporation
    公开号:US20150057265A1
    公开(公告)日:2015-02-26
    The present disclosure describes furo- and thieno-pyridine carboxamide compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
    本公开描述了呋喃和噻吩吡啶羧酰胺化合物,以及它们的组合物和使用方法。这些化合物抑制Pim激酶的活性,并且在治疗与Pim激酶活性相关的疾病方面具有用处,例如癌症和其他疾病。
  • Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
    申请人:Incyte Corporation
    公开号:US10000507B2
    公开(公告)日:2018-06-19
    The present disclosure describes furo- and thieno-pyridine carboxamide compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
    本公开描述了呋喃和噻吩吡啶羧酰胺化合物及其组合物和使用方法。这些化合物抑制 Pim 激酶的活性,可用于治疗与 Pim 激酶活性有关的疾病,包括癌症和其他疾病。
  • US9556197B2
    申请人:——
    公开号:US9556197B2
    公开(公告)日:2017-01-31
  • [EN] FURO- AND THIENO-PYRIDINE CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS<br/>[FR] COMPOSÉS DE FURO- ET THIÉNO-PYRIDINECARBOXAMIDE UTILES EN TANT QU'INHIBITEURS DE KINASES PIM
    申请人:INCYTE CORP
    公开号:WO2015027124A1
    公开(公告)日:2015-02-26
    The present disclosure describes furo-and thieno-pyridine carboxamide compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: X is S or 0; A5 is N or C-R5. CyA is a 5 to 6 membered monocyclic heteroaryl group, wherein the ring atoms of the heteroaryl group forming CyA consist of carbon atoms and 1, 2, or 3 heteroatoms selected from N, 0 and S, and wherein the 5 to 6 membered monocyclic heteroaryl group forming CyA is unsubstituted or substituted with 1, 2, or 3 RA; CyB is C6-10aryl, C3-7cycloalkyl, 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl wherein the ring atoms of the ring atoms of the heteroaryl or heterocycloalkyl forming CyB consist of carbon atoms and 1, 2 or 3 heteroatoms selected from 0, N and S, and wherein each of said C6-10aryl, C3-7cycloalkyl, 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl forming CyB is unsubstituted or substituted with 1, 2, 3, 4 or 5 RB; R2 is H, halogen or NH2; and R5, R6 and R7 are as defined in claim 1; The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
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