2-Bromo-4,6-dimethylpyridine-3-carbaldehyde | 942266-98-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Bromo-4,6-dimethylpyridine-3-carbaldehyde
• 英文别名: 2-bromo-4,6-dimethylpyridine-3-carbaldehyde
• CAS: 942266-98-0
• 化学式: C₈H₈BrNO
• 分子量: 214.062
• InChiKey: UBLDARJLZAUBJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Bromo-4,6-dimethylpyridine-3-carbaldehyde 、 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 生成 2-bromo-3-[(Z)-2-(2-bromo-4,6-dimethylpyridin-3-yl)ethenyl]quinoline 、
  参考文献：
  名称：

  A new approach to the 1,10-phenanthroline core

  摘要：

  A protocol for the synthesis of substituted 1,10-phenanthrolines is reported. The phenanthroline scaffold has been obtained constructing the central cycle starting from two pyridine rings. The method is hinged upon the intramolecular coupling of eiv-1,2-di(2-bromo-3-pyridyl)ethenes that are in turn obtained from the Wittig reaction of 2-bromonicotinalclehydes with phosphonium salts prepared from 2-bromo-3-(bromomethyl)pyridines. Yields up to 75% have been obtained. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.03.073
• 作为产物：
  描述：

  2-溴-3-氰基-4,6-二甲基吡啶 在 二异丁基氢化铝 作用下， 以 二氯甲烷 为溶剂， 以80%的产率得到2-Bromo-4,6-dimethylpyridine-3-carbaldehyde
  参考文献：
  名称：

  A new approach to the 1,10-phenanthroline core

  摘要：

  A protocol for the synthesis of substituted 1,10-phenanthrolines is reported. The phenanthroline scaffold has been obtained constructing the central cycle starting from two pyridine rings. The method is hinged upon the intramolecular coupling of eiv-1,2-di(2-bromo-3-pyridyl)ethenes that are in turn obtained from the Wittig reaction of 2-bromonicotinalclehydes with phosphonium salts prepared from 2-bromo-3-(bromomethyl)pyridines. Yields up to 75% have been obtained. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.03.073

文献信息

• A new approach to the 1,10-phenanthroline core
  作者：Giorgio Chelucci、Daniele Addis、Salvatore Baldino

  DOI：10.1016/j.tetlet.2007.03.073

  日期：2007.5

  A protocol for the synthesis of substituted 1,10-phenanthrolines is reported. The phenanthroline scaffold has been obtained constructing the central cycle starting from two pyridine rings. The method is hinged upon the intramolecular coupling of eiv-1,2-di(2-bromo-3-pyridyl)ethenes that are in turn obtained from the Wittig reaction of 2-bromonicotinalclehydes with phosphonium salts prepared from 2-bromo-3-(bromomethyl)pyridines. Yields up to 75% have been obtained. (c) 2007 Elsevier Ltd. All rights reserved.