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4-(2-吡咯烷基甲基)吗啉 | 215503-90-5

中文名称
4-(2-吡咯烷基甲基)吗啉
中文别名
——
英文名称
4-(S)-1-pyrrolidin-2-ylmethyl-morpholine
英文别名
(2R)-4-pyrrolidin-2-ylmethyl-morpholine;4-(Pyrrolidin-2-ylmethyl)morpholine
4-(2-吡咯烷基甲基)吗啉化学式
CAS
215503-90-5
化学式
C9H18N2O
mdl
MFCD06653314
分子量
170.255
InChiKey
UUUSROHBEMVRKP-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    255.4±15.0 °C(Predicted)
  • 密度:
    1.019±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    0
  • 重原子数:
    12
  • 可旋转键数:
    2
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    1.0
  • 拓扑面积:
    24.5
  • 氢给体数:
    1
  • 氢受体数:
    3

安全信息

  • 危险等级:
    IRRITANT
  • 海关编码:
    2934999090
  • 危险性防范说明:
    P261,P280,P301+P312,P302+P352,P305+P351+P338
  • 危险性描述:
    H302,H315,H319,H335

反应信息

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文献信息

  • CATALYST FOR ASYMMETRIC HYDROGENATION
    申请人:MAEDA Hironori
    公开号:US20100324338A1
    公开(公告)日:2010-12-23
    This invention aims at providing a catalyst for producing an optically active aldehyde or an optically active ketone, which is an optically active carbonyl compound, by carrying out selective asymmetric hydrogenation of an α,β-unsaturated carbonyl compound, particularly a catalyst which is insoluble in a reaction mixture for obtaining optically active citronellal which is useful as a flavor or fragrance, by carrying out selective asymmetric hydrogenation of citral, geranial or neral; and a method for producing a corresponding optically active carbonyl compound. The invention relates to a catalyst for asymmetric hydrogenation of an α,β-unsaturated carbonyl compound, which comprises a powder of at least one metal selected from metals belonging to Group 8 to Group 10 of the Periodic Table, or a metal-supported substance in which at least one metal selected from metals belonging to Group 8 to Group 10 of the Periodic Table is supported on a support, an optically active cyclic nitrogen-containing compound and an acid.
    这项发明旨在通过对α,β-不饱和羰基化合物进行选择性不对称加氢,特别是通过对柠檬醛、香叶醛或柠檬醛进行选择性不对称加氢,从而提供用作香料或香精的有用的光学活性香茅醛的催化剂,该香茅醛是一种光学活性羰基化合物;以及生产相应的光学活性羰基化合物的方法。该发明涉及一种用于不对称加氢α,β-不饱和羰基化合物的催化剂,其包括来自周期表第8至第10族金属中至少一种金属的粉末,或者至少一种来自周期表第8至第10族金属的金属负载物质,该金属负载在一种支撑物上,还包括光学活性的含氮环化合物和酸。
  • Sulfonamide lactam inhibitors of FXa and method
    申请人:——
    公开号:US20040186134A1
    公开(公告)日:2004-09-23
    Sulfonamide lactams of the following formula 1 wherein X, R 1 , R 2 , R 3 , R 4 , R 4a , R 5 , R 5a , R 6 , R 6a , R 7 and R 8 are as described herein, are provided which inhibitors of Factor Xa and are useful as anticoagulants in the treatment of cardiovascular diseases associated with thromboses.
    以下式子中的磺胺酰胺内酰胺,其中X、R1、R2、R3、R4、R4a、R5、R5a、R6、R6a、R7和R8如本文所述,被提供为因子Xa的抑制剂,并且在治疗与血栓相关的心血管疾病中作为抗凝剂是有用的。
  • Thiophene derivatives useful as anticancer agents
    申请人:——
    公开号:US20020042409A1
    公开(公告)日:2002-04-11
    The invention relates to compounds of the formula 1 1 or a pharmaceutically acceptable salt and to pharmaceutically acceptable salts and hydrates thereof, wherein X, Y, R 1 , R 2 and R 11 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.
    该发明涉及公式11的化合物或其药用可接受盐,以及其药用可接受盐和水合物,其中X、Y、R1、R2和R11如本文所定义。该发明还涉及含有公式1化合物的药物组合物,以及通过给哺乳动物施用公式1化合物来治疗过度增殖性疾病的方法。
  • PEPTIDE DEFORMYLASE INHIBITORS
    申请人:Qin Donghui
    公开号:US20090306066A1
    公开(公告)日:2009-12-10
    The present invention is directed to certain 2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives, compositions containing them, the use of such compounds in the inhibition of bacterial peptide deformylase (PDF) activity, and in the treatment of bacterial infections. Specifically, the invention is directed to compounds of formula (I): wherein R1, R2 and R3 are defined herein and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.
    本发明涉及某些2-(烷基)-3-[2-(5-氟-4-嘧啶基)肼基]-3-氧代丙基}羟基甲酰胺衍生物,包含它们的组合物,这些化合物在抑制细菌肽变形酶(PDF)活性和治疗细菌感染方面的使用。具体而言,本发明涉及式(I)的化合物:其中R1,R2和R3在此定义,并且其药学上可接受的盐。本发明的化合物是细菌肽变形酶抑制剂,可用于治疗细菌感染。
  • QUINOLINE-CARBOXAMIDE DERIVATIVES AS P2Y12 ANTAGONISTS
    申请人:Nazaré Marc
    公开号:US20100135999A1
    公开(公告)日:2010-06-03
    The present invention relates to compounds of the formula I, in which R 1 ; R 2 ; R 3 ; R 4 ; R 5 ; R 6 ; Z; A; B; E; X; Q; J; V; G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong anti-aggregating effect on platelets and thus an anti-thrombotic effect and are suitable e.g. for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are reversible antagonists of the platelet ADP receptor P2Y12, and can in general be applied in conditions in which an undesired activation of the platelet ADP receptor P2Y12 is present or for the cure or prevention of which an inhibition of the platelet ADP receptor P2Y12 is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
    本发明涉及公式I的化合物,其中R1; R2; R3; R4; R5; R6; Z; A; B; E; X; Q; J; V; G和M具有所述声明中指示的含义。公式I的化合物是有价值的药理活性化合物。它们对血小板具有强烈的抗聚集作用,从而具有抗血栓作用,适用于治疗和预防心血管疾病,如血栓栓塞病或再狭窄。它们是血小板ADP受体P2Y12的可逆拮抗剂,通常适用于存在不良激活血小板ADP受体P2Y12的情况,或者治愈或预防需要抑制血小板ADP受体P2Y12的情况。此外,本发明还涉及制备公式I化合物的方法,它们的用途,特别是作为药物中的活性成分,以及包含它们的制药制剂。
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