Gadolinium;2-hydroxypropane-1,2,3-tricarboxylic acid | 3088-53-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Gadolinium;2-hydroxypropane-1,2,3-tricarboxylic acid
• 英文别名: gadolinium;2-hydroxypropane-1,2,3-tricarboxylic acid
• CAS: 3088-53-7
• 化学式: C6H8GdO7
• 分子量: 349.4
• InChiKey: SOLCIIRUZZRDCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.25
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  132
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Polymerization method for the synthesis of polypeptide imaging agents
  申请人：Grimmond James Brian

  公开号：US20060104908A1

  公开（公告）日：2006-05-18

  A method for synthesizing extended poly(amino acids) conjugated to imaging agents, such as DTPA, is disclosed. The amino acid is initially conjugated to the imaging agent at the monomer stage, followed by formation of the corresponding N-carboxyanhydride. The method utilizes catalyzed ring opening polymerization of the N-carboxyanhydride of the amino acid-imaging agent monomer allowing the formation of a poly(amino acid) backbone having 100% imaging agent conjugation if desired. However, the present method also permits the degree of conjugation to be controlled by copolymerizing the N-carboxyanhydride of the amino acid-imaging agent monomer with one or more unconjugated monomers, i.e. N-carboxyanhydrides of the same or of other amino acids. Various imaging agents may be employed, and new hybrid random, block, and mixed copolymers may be prepared.

  揭示了一种用于合成与成像剂（如DTPA）共轭的扩展型聚（氨基酸）的方法。氨基酸最初在单体阶段与成像剂共轭，然后形成相应的N-羧酸酐。该方法利用氨基酸-成像剂单体的N-羧酸酐的催化环开聚合，允许形成具有100%成像剂共轭的聚（氨基酸）骨架，如果需要的话。然而，该方法还允许通过与一个或多个未共轭单体共聚合，即氨基酸-成像剂单体的N-羧酸酐与相同或其他氨基酸的N-羧酸酐共聚合，来控制共轭程度。可以使用各种成像剂，并可以制备新的混合随机、块状和混合共聚物。
• CHELATOR-FUNCTIONALIZED NANOPARTICLES
  申请人：Ding Zhebo

  公开号：US20090087381A1

  公开（公告）日：2009-04-02

  Provided herein are chelator-functionalized nanoparticles comprising a passive core; and an active coating that demonstrate T1 magnetic resonance pattern upon exposure to a magnetic field. Also provided are methods of making such chelator-functionalized nanoparticles as well as imaging methods using the nanoparticles.

  本文提供了一种螯合剂功能化的纳米颗粒，包括一个被动核心和一个活性涂层。在暴露于磁场下时，这些颗粒表现出T1磁共振图案。还提供了制备这种螯合剂功能化的纳米颗粒的方法以及使用这些颗粒的成像方法。
• Synthesis of highly conjugated polymers
  申请人：——

  公开号：US20040022857A1

  公开（公告）日：2004-02-05

  Improved methods for forming substituted polymers having a high degree of conjugation include the steps of activating a steric hindrance molecule under conditions that ensure substantially all the steric hindrance molecules are mono-activated and then reacting with a polymer. An improved method for recovering polypeptides substituted with steric hindrance molecules and having an elongate configuration removes impurities and volatiles without achieving complete dryness of the copolymer.

  形成具有高度共轭的取代聚合物的改进方法包括以下步骤：在确保基本上所有的立体阻碍分子都被单活化的条件下活化立体阻碍分子，然后与聚合物反应。一种用于回收被立体阻碍分子取代并具有细长构型的多肽的改进方法，可以去除杂质和挥发物，而不会使共聚物完全干燥。
• Method for assessing myocardial angiogenesis
  申请人：——

  公开号：US20040024318A1

  公开（公告）日：2004-02-05

  Polymeric contrast agents are used to monitor myocardial neovascularization. The agent is injected and images of the myocardium are obtained at various time intervals after injection. Localized image enhancement indicates an area of increased angiogenesis.

  聚合物造影剂用于监测心肌新生血管。注射造影剂后，在不同的时间间隔采集心肌图像。局部图像增强表明该区域血管生成增加。
• Magnetic resonance contrast-enhancing agents and method for detecting and imaging artherosclerotic plaque
  申请人：——

  公开号：US20040265235A1

  公开（公告）日：2004-12-30

  Magnetic resonance (“MR”) contrast-enhancing agents comprise poly(amino acid) backbone chain conjugated to chelating moieties that comprise a plurality of carboxylic acid groups that form coordination complexes with paramagnetic ions. A method for detecting atherosclerotic plaque areas comprises administering at least one of these contrast agents into a subject; and obtaining and comparing MR images of and MR signals from the plaque areas before and after administering the contrast agent. The method can be used to assess an effectiveness of a prescribed course of treatment for atherosclerosis.

  磁共振（"MR"）造影剂包括与螯合分子共轭的聚（氨基酸）骨架链，螯合分子包括多个羧酸基团，这些羧酸基团与顺磁离子形成配位络合物。检测动脉粥样硬化斑块区域的方法包括：向受试者施用至少一种此类造影剂；以及获取并比较施用造影剂前后斑块区域的磁共振图像和磁共振信号。该方法可用于评估动脉粥样硬化规定疗程的有效性。