[(1R,2R,3S,4S)-3-[[(2S)-2-(methylamino)-3-phenylpropanoyl]oxymethyl]-2-bicyclo[2.2.1]hept-5-enyl]methyl (2S)-2-(methylamino)-3-phenylpropanoate | 1174987-70-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [(1R,2R,3S,4S)-3-[[(2S)-2-(methylamino)-3-phenylpropanoyl]oxymethyl]-2-bicyclo[2.2.1]hept-5-enyl]methyl (2S)-2-(methylamino)-3-phenylpropanoate
• CAS: 1174987-70-2
• 化学式: C₂₉H₃₆N₂O₄
• 分子量: 476.616
• InChiKey: XFEIFNZRMQHQJE-AKCFYGDASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  35
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  ((1R,2R,3S,4S)-bicyclo[2.2.1]hept-5-ene-2,3-diyl)bis(methylene) (2S,2'S)-bis(2-((tert-butoxycarbonyl)(methyl)amino)-3-phenylpropanoate) 在 三氟乙酸 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 以80%的产率得到[(1R,2R,3S,4S)-3-[[(2S)-2-(methylamino)-3-phenylpropanoyl]oxymethyl]-2-bicyclo[2.2.1]hept-5-enyl]methyl (2S)-2-(methylamino)-3-phenylpropanoate
  参考文献：
  名称：

  Alternating Ring-Opening Metathesis Copolymerization of Amino Acid Derived Norbornene Monomers Carrying Nonprotected Carboxy and Amino Groups Based on Acid−Base Interaction

  摘要：

  Amino acid derived norbomene monomers having carboxy (1) and amino groups (2) were synthesized and subjected to ring-opening metathesis copolymerization with various feed ratios using the Grubbs second generation ruthenium catalyst. The M-n's of the copolymers ranged from 5300 to 9400 (M-w/M-n = 1.40-1.69). The monomer conversion and M-n of the copolymer were maximized when the monomer feed ratio was 1:1. The monomer unit ratios in the copolymers were almost 1:1 at 10% conversion, irrespective of the feed ratios. The monomer reactivity ratios r(1) and r(2) were estimated to be 0.08 and 0.02, which confirmed that alternating copolymerization occurred. It is considered that alternating copolymerization is brought about by the acid-base interaction between the monomers and/or between the propagating polymer end and the incoming monomer.

  DOI：

  10.1021/ja903248c

文献信息

• Alternating Ring-Opening Metathesis Copolymerization of Amino Acid Derived Norbornene Monomers Carrying Nonprotected Carboxy and Amino Groups Based on Acid−Base Interaction
  作者：Sutthira Sutthasupa、Masashi Shiotsuki、Toshio Masuda、Fumio Sanda

  DOI：10.1021/ja903248c

  日期：2009.8.5

  Amino acid derived norbomene monomers having carboxy (1) and amino groups (2) were synthesized and subjected to ring-opening metathesis copolymerization with various feed ratios using the Grubbs second generation ruthenium catalyst. The M-n's of the copolymers ranged from 5300 to 9400 (M-w/M-n = 1.40-1.69). The monomer conversion and M-n of the copolymer were maximized when the monomer feed ratio was 1:1. The monomer unit ratios in the copolymers were almost 1:1 at 10% conversion, irrespective of the feed ratios. The monomer reactivity ratios r(1) and r(2) were estimated to be 0.08 and 0.02, which confirmed that alternating copolymerization occurred. It is considered that alternating copolymerization is brought about by the acid-base interaction between the monomers and/or between the propagating polymer end and the incoming monomer.