(R)-N-[1-[4-(Acetyl-phenyl-amino)-piperidine-1-carbonyl]-2-(1H-indol-3-yl)-ethyl]-2-amino-isobutyramide | 185056-07-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-N-[1-[4-(Acetyl-phenyl-amino)-piperidine-1-carbonyl]-2-(1H-indol-3-yl)-ethyl]-2-amino-isobutyramide
• 英文别名: N-[(2R)-1-[4-(N-acetylanilino)piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-amino-2-methylpropanamide
• CAS: 185056-07-9
• 化学式: C₂₈H₃₅N₅O₃
• 分子量: 489.618
• InChiKey: XIWLQRJTTVLZQJ-RUZDIDTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE
  申请人：PFIZER INC.

  公开号：EP0828754A1

  公开（公告）日：1998-03-18
• 11-DEOXY AZALIDE ANTIBACTERIALS
  申请人：Abbott Laboratories

  公开号：EP1501847A2

  公开（公告）日：2005-02-02
• [EN] DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE<br/>[FR] DIPEPTIDES FAVORISANT LA SECRETION DE L'HORMONE DE CROISSANCE
  申请人：PFIZER INC.

  公开号：WO1996038471A1

  公开（公告）日：1996-12-05

  (EN) Compounds of formula (I) are growth hormone releasing peptide mimetics which are useful for the treatment and prevention of osteoporosis.(FR) L'invention se rapporte aux composés de la formule (I). Il s'agit de mimétiques des peptides favorisant la secrétion de l'hormone de croissance, qui sont utiles pour le traitement et la prévention de l'ostéoporose.
• [EN] DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE<br/>[FR] DIPEPTIDES STIMULANT LA LIBERATION DE L'HORMONE DE CROISSANCE
  申请人：PFIZER, INC.

  公开号：WO1996035713A1

  公开（公告）日：1996-11-14

  (EN) Compounds of formula (I) are growth hormone releasing peptide mimetics which are useful for the treatment and prevention of osteoporosis.(FR) Les composés de formule (I) sont des substances mimétiques peptidiques libérant l'hormone de croissance, utiles pour traiter et prévenir l'ostéoporose.
• [EN] 11-DEOXY AZALIDE ANTIBACTERIALS<br/>[FR] ANTIBACTERIENS DE 11-DESOXY AZALIDE
  申请人：ABBOTT LAB

  公开号：WO2003090679A2

  公开（公告）日：2003-11-06

  Antibacterial compounds having formula (I) and formula (II), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.