Methyl-p-methoxyphenylglyoxylat-hydrazon | 22979-34-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Methyl-p-methoxyphenylglyoxylat-hydrazon
• CAS: 22979-34-6
• 化学式: C₁₀H₁₂N₂O₃
• 分子量: 208.217
• InChiKey: KJWXDHRDKIMTME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.53
• 重原子数：
  15.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  73.91
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  Methyl-p-methoxyphenylglyoxylat-hydrazon 在 lead(IV) acetate 作用下， 生成 methyl 2-diazo-2-(4-methoxypheny)acetate
  参考文献：
  名称：

  A ketenimine from the addition of a carbene to an isocyanide

  摘要：

  DOI：

  10.1021/jo00828a085
• 作为产物：
  描述：

  甲基戊酰氯 、 苯甲醚 生成 Methyl-p-methoxyphenylglyoxylat-hydrazon
  参考文献：
  名称：

  A ketenimine from the addition of a carbene to an isocyanide

  摘要：

  DOI：

  10.1021/jo00828a085

文献信息

• Regio- and Diastereoselective Construction of α-Hydroxy-δ-amino Ester Derivatives via 1,4-Conjugate Addition of β,γ-Unsaturated <i>N</i>-Sulfonylimines
  作者：Lin Qiu、Lixin Gao、Jixing Tang、Dongwei Wang、Xin Guo、Shunying Liu、Liping Yang、Jia Li、Wenhao Hu

  DOI：10.1021/jo500176g

  日期：2014.5.2

  A first example of 1,4-conjugate addition of beta,gamma-unsaturated N-sulfonylimines via the oxonium ylides trapping process was developed. This method afforded a novel and efficient access for the high regio- and diastereoselective construction of alpha-hydroxyl-delta-amino esters derivatives, which exhibit inhibitory activity on PTP1B and SIRT1 enzymes in vitro. The synthetic potentials and the biological activity of the resulting products were well demonstrated to be promising for drug discovery.