(3-Methoxy-5-methyl-phenyl)-methyl-amine | 35122-78-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (3-Methoxy-5-methyl-phenyl)-methyl-amine
• 英文别名: 3-methoxy-N,5-dimethylaniline
• CAS: 35122-78-2
• 化学式: C₉H₁₃NO
• 分子量: 151.208
• InChiKey: FYYCUOMESGVPBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] PROCESS FOR PREPARING N-SUBSTITUTED 1H-PYRAZOLE-5-CARBOXYLIC ACID COMPOUNDS AND DERIVATIVES THEREOF<br/>[FR] PROCÉDÉ DE PRÉPARATION DE COMPOSÉS ACIDE 1H-PYRAZOLE-5-CARBOXYLIQUE N-SUBSTITUÉS ET DE LEURS DÉRIVÉS
  申请人：BASF SE

  公开号：WO2014184343A1

  公开（公告）日：2014-11-20

  The present invention relates to a process for preparing N-substituted 1 H-pyrazole-5-carboxylic acid compounds of the formula l-A and derivatives thereof, in particular the corresponding carbonylchloride compounds (acid chlorides). It also relates to the use of these acid chlorides for preparing anthranilamide derivatives that are useful pesticides. in which the variables are as defined in the claims and the specification comprising the steps of i) reacting a compound of the formula (II) with a base selected from combinations of a magnesium-organic compound having a carbon bound magnesium and a secondary amine and magnesium amides of secondary amines in the presence of a lithium halide, where the base is used in an amount sufficient to achieve at least 80 % deprotonation of the compound of formula (II); and subjecting the product obtained in step (i) to a carboxylation by reacting it with carbon dioxide or a carbon dioxide equivalent, to obtain a magnesium salt of the compound of formula (l-A) and optionally aqueous workup to obtain the compound of the formula (l-A) as a free acid.

  本发明涉及一种制备N-取代1H-吡唑-5-羧酸化合物及其衍生物的方法，特别是相应的羰基氯化合物（酸氯化物）。还涉及使用这些酸氯化物来制备对昆虫有用的蒽醯胺衍生物杀虫剂。其中变量如索赔中所定义和规范中包括以下步骤：i）将式（II）的化合物与选择自具有碳键镁的有机镁化合物和次级胺以及次级胺的镁酰胺的组合的碱在锂卤化物存在下反应，其中所述碱的用量足以实现式（II）的化合物至少80%的脱质子化；并将在步骤（i）中获得的产物经羧化反应，与二氧化碳或二氧化碳等效物反应，以获得化合物的镁盐（l-A）和可选的水工艺处理以获得化合物的自由酸形式（l-A）。
• Heterocyclic compounds and their use as anticancer agents
  申请人：Chen Xiaoling

  公开号：US20090318438A1

  公开（公告）日：2009-12-24

  The present invention relates to heterocyclic compounds that have anticancer activity, and pharmaceutical compositions that contain such compounds, methods of treating diseases and conditions in mammals using such compounds and composition and methods for their manufacture.

  本发明涉及具有抗癌活性的杂环化合物，以及包含这些化合物的制药组合物，使用这些化合物和组合物治疗哺乳动物的疾病和病症的方法以及它们的制造方法。
• SHIP1 MODULATORS AND METHODS RELATED THERETO
  申请人：AQUINOX PHARMACEUTICALS (CANADA) INC.

  公开号：US20150336935A1

  公开（公告）日：2015-11-26

  Compounds of formula (I): where, n, R 1 , R 4a , R 4b , R 5 , R 7 and R 8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.

  公式（I）的化合物：其中，n，R1，R4a，R4b，R5，R7和R8的定义如本文所述，或其药学上可接受的盐，在此处进行描述。所披露的化合物具有SHIP1调节剂的活性，因此可用于治疗任何需要SHIP1调节的多种疾病，疾病或状况。本文还披露了包含公式（I）化合物与药学上可接受的载体或稀释剂组合的组合物，以及通过向需要此类化合物的动物施用来进行SHIP1调节的方法。
• SPIROIMIDAZOLONE DERIVATIVE
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：EP2433940A1

  公开（公告）日：2012-03-28

  The present invention relates to a compound represented by the following formula (1): wherein W, X, Y, R1, R2, R33, R34, m and n are as defined in the claims, or a pharmacologically acceptable salt thereof.

  本发明涉及下式（1）所代表的化合物： 其中 W、X、Y、R1、R2、R33、R34、m 和 n 如权利要求中定义，或其药理上可接受的盐。
• PROCESS FOR PREPARING N-SUBSTITUTED 1H-PYRAZOLE-5-CARBOXYLIC ACID COMPOUNDS AND DERIVATIVES THEREOF
  申请人：BASF SE

  公开号：EP2997020A1

  公开（公告）日：2016-03-23