1-(2,4-Dibromo-5-methoxyphenyl)sulfanylpyrrolidine-2,5-dione | 1618674-47-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(2,4-Dibromo-5-methoxyphenyl)sulfanylpyrrolidine-2,5-dione
• 英文别名: 1-(2,4-dibromo-5-methoxyphenyl)sulfanylpyrrolidine-2,5-dione
• CAS: 1618674-47-7
• 化学式: C₁₁H₉Br₂NO₃S
• 分子量: 395.071
• InChiKey: AIQCXRIVXSZACG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  71.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-叔丁基苯胺 、 1-(2,4-Dibromo-5-methoxyphenyl)sulfanylpyrrolidine-2,5-dione 以 乙腈 为溶剂， 反应 21.0h， 以90%的产率得到4-t-butyl-2-(2,4-dibromo-5-methoxyphenylthio)aniline
  参考文献：
  名称：

  （芳硫基）-吡咯烷-2,5-二酮与芳胺衍生物的芳硫基化

  摘要：

  AbstractA simple and efficient method for arylthiolation of arylamines has been developed. The protocol uses (arylthio)pyrrolidine‐2,5‐diones as the arylthiolating reagents, acetonitrile as the solvent, and no catalyst and additive are required, which avoids contamination from the transition metal catalysts in the target products. Therefore, the present method should provide a convenient, efficient and practical strategy for the synthesis of other aryl sulfides.magnified image

  DOI：

  10.1002/adsc.201400929

文献信息

• Iron or boron-catalyzed C–H arylthiation of substituted phenols at room temperature
  作者：Hua Tian、Changjin Zhu、Haijun Yang、Hua Fu

  DOI：10.1039/c4cc03600j

  日期：——

  A simple, efficient and environmentally friendly method for iron or boron-catalyzed C–H arylthiation of substituted phenols at room temperature has been developed, and the corresponding diaryl sulfides were prepared in good to excellent yields.

  已开发出一种简单、高效且环保的方法，可在室温下通过铁或硼催化的方式对取代酚进行C-H芳基硫化，从而制备出相应的二芳基硫化物，产率在良好至优秀之间。
• Catalyst-Free Isothiocyanatoalkylthiation of Styrenes with (Alkylthio)pyrrolidine-2,5-diones and Trimethylsilyl Isothiocyanate
  作者：Hua Tian、Jipan Yu、Haijun Yang、Changjin Zhu、Hua Fu

  DOI：10.1002/adsc.201501181

  日期：2016.6.2

  A simple and efficient catalyst‐free method for isothiocyanatoalkylthiation of styrenes has been developed. The protocol uses (alkylthio)pyrrolidine‐2,5‐diones and trimethylsilyl isothiocyanate as the isothiocyanatoalkylthiolating reagents, dimethylformamide (DMF) as the solvent, and the reactions were completed within one hour with tolerance of some functional groups. No catalyst and additive were

  已经开发出一种简单高效的无催化剂的苯乙烯异硫氰酸根合烷基化方法。该方案使用（烷硫基）吡咯烷-2,5-二酮和异硫氰酸三甲基硅烷基酯作为异硫氰酸根合烷基硫醇化试剂，二甲基甲酰胺（DMF）作为溶剂，反应在1小时内完成，且具有一定的官能团耐受性。在反应体系中不需要催化剂和添加剂，避免了目标产物中过渡金属催化剂的任何污染。因此，本方法为通过硫化物和异硫氰酸酯的组合合成化合物提供了方便，有效和实用的策略。