N-(4-methoxybenzyl)-1,8-naphthalimide | 186298-99-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: N-(4-methoxybenzyl)-1,8-naphthalimide
• 英文别名: 2-(4-methoxybenzyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione；2-[(4-methoxyphenyl)methyl]benzo[de]isoquinoline-1,3-dione
• CAS: 186298-99-7
• 化学式: C₂₀H₁₅NO₃
• 分子量: 317.344
• InChiKey: IQOALYXGGXPZQO-UHFFFAOYSA-N

物化性质

• 沸点：
  520.7±33.0 °C(Predicted)
• 密度：
  1.327±0.06 g/cm3(Predicted)
• 溶解度：
  0.9 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(4-methoxybenzyl)-1,8-naphthalimide 在 N-甲基咪唑 、 1,5-二氮杂双环[4.3.0]壬-5-烯 、 sodium t-butanolate 作用下， 反应 10.0h， 以95%的产率得到颜料黑32
  参考文献：
  名称：

  一种苝系颜料的制备方法

  摘要：

  本发明提供一种苝系颜料的制备方法，是采用N‑取代‑1,8‑萘酰亚胺为起始原料，以N‑甲基咪唑与DBU或N‑甲基咪唑与DBN的混合溶剂为反应介质，醇钠或醇钾为催化剂，经130‑170℃反应3‑10小时，反应结束后，反应体系降温，减压浓缩，回收反应溶剂，收集产物制得苝系颜料。制备的苝系颜料色力高，颜色鲜艳，分散性好，且此工艺简单，耗时短，反应温度低，减少强碱和浓硫酸使用，降低了生产成本，减少废水和固废排放。

  公开号：

  CN109535767B
• 作为产物：
  描述：

  萘亚胺 、 4-甲氧基氯苄 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以50%的产率得到N-(4-methoxybenzyl)-1,8-naphthalimide
  参考文献：
  名称：

  Naphthalimido derivatives as antifolate thymidylate synthase inhibitors

  摘要：

  A new series of N-(substituted)benzyl-1,8-naphthalimides 4, structurally related to the previously reported thymidylate synthase (TS) inhibitor naphthaleins 3, were synthesized and compounds tested for their inhibition of several species of TS. Moreover, their in vitro cytotoxicity together with antimycotic and antibacterial properties were assayed. While no activity was detected in the antibacterial tests, the m-nitro (4ae) and the p-nitro (4af) derivatives were found able to partially inhibit TS at low micromolar concentrations. Introduction of nitro or (substituted)-amino groups in position 4 of the naphthalic ring always led to less active compounds.

  DOI：

  10.1016/s0223-5234(97)86180-6

文献信息

• Greener Dye Synthesis: Continuous, Solvent‐Free Synthesis of Commodity Perylene Diimides by Twin‐Screw Extrusion
  作者：Qun Cao、Deborah E. Crawford、Chengcheng Shi、Stuart L. James

  DOI：10.1002/anie.201913625

  日期：2020.3.9

  synthesis of more difficult aniline-derived PDIs. Furthermore, an automated continuous TSE process for Pigments Black 31 and 32 is demonstrated, with a throughput rate of about 1500 g day-1 , corresponding to a space time yield of about 30×103  kg m-3  day-1 , which is 1-2 orders of magnitude greater than for solvent-based batch methods. These methods provide substantial waste reductions and improved

  报道了一种使用双螺杆挤出（TSE）合成各种萘酰亚胺和di二酰亚胺（PDI）的连续，可扩展且无溶剂的方法。使用TSE，无需过量的胺反应物或产物纯化即可定量获得萘酰亚胺。具有良好的官能团耐受性，以50-99％的产率获得了烷基和苄胺衍生的PDI（包括商业染料）。使用K2 CO3可以合成更困难的苯胺衍生PDI。此外，展示了用于颜料黑31和32的自动化连续TSE工艺，其吞吐速率约为1500 g day-1，对应于约30×103 kg m-3 day-1的时空产量，即1比基于溶剂的批处理方法大-2个数量级。
• Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: Anti-inflammatory and analgesic activities
  作者：Amer M. Alanazi、Adel S. El-Azab、Ibrahim A. Al-Suwaidan、Kamal Eldin H. ElTahir、Yousif A. Asiri、Naglaa I. Abdel-Aziz、Alaa A.-M. Abdel-Aziz

  DOI：10.1016/j.ejmech.2014.12.039

  日期：2015.3

  A group of 30 cyclic imides (1-10a-c) was designed for evaluation as a selective COX-2 inhibitor and investigated in vivo for anti-inflammatory and analgesic activities. Compounds 6a, 6b, 7a and 7b exhibit optimal COX-2 inhibitory potency (IC50 = 0.18, 0.24, 0.28 and 036 AM; respectively) and selectivity index (SI) range of 363-668. In vitro COX-1/COX-2 inhibition structure activity studies identified compound 6a as a highly potent (IC50 = 0.18 AM), and an extremely selective [COX-2 (SI) = 668] comparable to celecoxib [COX-2 (SI) > 384], COX-2 inhibitor that showed superior anti-inflammatory activity (ED50 = 54.0 mg/kg) relative to didofenac (ED50 = 114 mg/kg). Molecular Docking study of the synthesized compound 6a into the active site of COX-2 revealed a similar binding mode to SC-558, a selective COX-2 inhibitor. Docking study showed that the methoxy moeities of 6a inserted deep inside the 2 degrees-pocket of the COX-2 active site, where the O-atoms of such groups underwent an H-bonding interaction with His(90) (3.02 angstrom), Arg(513) (1.94, 2.83 angstrom), and Gln(192) (3.25 angstrom). (C) 2014 Elsevier Masson SAS. All rights reserved.