1-Tert-butyl-5-(4-chlorophenyl)-5-hydroxy-3-phenylpyrrol-2-one | 1258789-42-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 1-Tert-butyl-5-(4-chlorophenyl)-5-hydroxy-3-phenylpyrrol-2-one
• 英文别名: 1-tert-butyl-5-(4-chlorophenyl)-5-hydroxy-3-phenylpyrrol-2-one
• CAS: 1258789-42-2
• 化学式: C₂₀H₂₀ClNO₂
• 分子量: 341.837
• InChiKey: LZHOHVUMKGIJIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  异氰酸叔丁酯 、 4'-chlorochalcone 在 polystyrene-supported p-toluenesulfonic acid 作用下， 以86%的产率得到1-Tert-butyl-5-(4-chlorophenyl)-5-hydroxy-3-phenylpyrrol-2-one
  参考文献：
  名称：

  Supported p-Toluenesulfonic Acid as a Highly Robust and Eco-Friendly Isocyanide Scavenger

  摘要：

  We document here the use of polymer-supported p-toluenesulfonic acid as a highly effective, robust, economical and eco-friendly isocyanide scavenger. The herein described strategy; circumvent the intense and repulsive odor of volatile isocyanides, enabling simplified and odorless workup and purifications. The usefulness of the new scavengers has been validated in a set of diverse isocyanide-based organic transformations and this approach is also amenable to parallel synthesis techniques.

  DOI：

  10.1021/co100035z

文献信息

• Supported <i>p</i>-Toluenesulfonic Acid as a Highly Robust and Eco-Friendly Isocyanide Scavenger
  作者：Jhonny Azuaje、Alberto Coelho、Abdelaziz El Maatougui、José Manuel Blanco、Eddy Sotelo

  DOI：10.1021/co100035z

  日期：2011.1.10

  We document here the use of polymer-supported p-toluenesulfonic acid as a highly effective, robust, economical and eco-friendly isocyanide scavenger. The herein described strategy; circumvent the intense and repulsive odor of volatile isocyanides, enabling simplified and odorless workup and purifications. The usefulness of the new scavengers has been validated in a set of diverse isocyanide-based organic transformations and this approach is also amenable to parallel synthesis techniques.