1,3-Dimethyl-2-aza-anthrachinon | 95444-77-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 1,3-Dimethyl-2-aza-anthrachinon
• 英文别名: 1,3-dimethyl-benzo[g]isoquinoline-5,10-dione；1,3-Dimethylbenzo[g]isoquinoline-5,10-dione；1,3-dimethylbenzo[g]isoquinoline-5,10-dione
• CAS: 95444-77-2
• 化学式: C₁₅H₁₁NO₂
• 分子量: 237.258
• InChiKey: HMZFXTDYIACGGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  47
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-乙酰基萘-1,4-二酮 在 ammonium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 2.0h， 生成 1,3-Dimethyl-2-aza-anthrachinon
  参考文献：
  名称：

  One-pot synthesis of isoquinoline-5,8-dione derivatives from acylquinones and enamines

  摘要：

  A new and facile method for the preparation of isoquinolinequinone derivatives has been developed. Treatment of l-acyl-l,4-naphthoquinones or 2-acyl-5,6-dimethyl-1,4-benzoquinones with enamines (or imines), followed by addition of aqueous NH3 in MeOH afforded benz[g]isoquinoline-5,10-dione or isoquinoline-5,8-dione derivatives, respectively, in moderate to good yields. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01313-7

文献信息

• One-pot synthesis of isoquinoline-5,8-dione derivatives from acylquinones and enamines
  作者：Kazuhiro Kobayashi、Atsushi Takanohashi、Shinya Watanabe、Osamu Morikawa、Hisatoshi Konishi

  DOI：10.1016/s0040-4039(00)01313-7

  日期：2000.9

  A new and facile method for the preparation of isoquinolinequinone derivatives has been developed. Treatment of l-acyl-l,4-naphthoquinones or 2-acyl-5,6-dimethyl-1,4-benzoquinones with enamines (or imines), followed by addition of aqueous NH3 in MeOH afforded benz[g]isoquinoline-5,10-dione or isoquinoline-5,8-dione derivatives, respectively, in moderate to good yields. (C) 2000 Elsevier Science Ltd. All rights reserved.