[Benzyloxycarbonyl-(2,2,2-trifluoro-ethyl)-amino]-acetic acid 4-nitro-phenyl ester | 199340-79-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [Benzyloxycarbonyl-(2,2,2-trifluoro-ethyl)-amino]-acetic acid 4-nitro-phenyl ester
• 英文别名: N-[(Phenylmethoxy)carbonyl]-N-(2,2,2-trifluoroethyl)glycine 4-nitrophenyl ester；(4-nitrophenyl) 2-[phenylmethoxycarbonyl(2,2,2-trifluoroethyl)amino]acetate
• CAS: 199340-79-9
• 化学式: C₁₈H₁₅F₃N₂O₆
• 分子量: 412.322
• InChiKey: NBSBGVGACWNVTM-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  [Benzyloxycarbonyl-(2,2,2-trifluoro-ethyl)-amino]-acetic acid 4-nitro-phenyl ester 、 N-[(S)-1-{3-[4-(3-Amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-fluoro-phenyl)-ethyl]-butyramide 以 甲醇 为溶剂， 反应 12.0h， 以86%的产率得到{[3-(4-{3-[(S)-2-Butyrylamino-3-(4-fluoro-phenyl)-propionylamino]-propylamino}-butylamino)-propylcarbamoyl]-methyl}-(2,2,2-trifluoro-ethyl)-carbamic acid benzyl ester
  参考文献：
  名称：

  Structure-binding relation of philanthotoxins from nicotinic acetylcholine receptor binding assay

  摘要：

  Philanthotoxins are noncompetitive inhibitors of the nicotinic acetylcholine receptor and the Various glutamate receptors. Analogues carrying photoaffinity labels, fluorine atoms for solid-state NMR studies of ligand/receptor interaction, and large head groups such as porphyrins and planar bulky aromatic rings (BIG analogues) for clarifying mode of entry and orientation of analogues in receptors have been synthesized, assayed against the nicotinic acetylcholine receptor, and brief comments are given for the assay results. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(97)00137-5