Ble4rdc8EG | 3023294-04-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ble4rdc8EG
• 英文别名: 8-acetyloxy-2,2,14,14-tetramethylpentadecanedioic acid
• CAS: 3023294-04-1
• 化学式: C₂₁H₃₈O₆
• 分子量: 386.5
• InChiKey: AOLKKNNGXIATAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  27
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] METHODS OF MAKING BEMPEDOIC ACID AND COMPOSITIONS OF THE SAME<br/>[FR] PROCÉDÉS DE PRÉPARATION D'ACIDE BEMPÉDOÏQUE ET COMPOSITIONS DE CELUI-CI
  申请人：ESPERION THERAPEUTICS INC

  公开号：WO2020257571A1

  公开（公告）日：2020-12-24

  The invention provides methods of preparing 8-hy droxy-2,2, 14,14- tetramethylpentadecanedioic acid and methods of making a pharmaceutical material comprising a purified amount of 8-hy droxy-2,2, 14, 14-tetramethylpentadecanedioic acid. Also provided are compositions and pharmaceutical materials including a purified amount of 8- hydroxy-2,2, 14, 14-tetramethylpentadecanedioic acid as well as methods of treating various diseases and conditions using the compositions and pharmaceutical materials.

  该发明提供了制备8-羟基-2,2,14,14-四甲基十五烷二酸的方法，以及制备含有纯化量8-羟基-2,2,14,14-四甲基十五烷二酸的药用材料的方法。还提供了包括纯化量8-羟基-2,2,14,14-四甲基十五烷二酸的组合物和药用材料，以及使用这些组合物和药用材料治疗各种疾病和症状的方法。
• Methods of making bempedoic acid and compositions of the same
  申请人：Esperion Therapeutics, Inc.

  公开号：US11407705B2

  公开（公告）日：2022-08-09

  The invention provides methods of preparing 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid and methods of making a pharmaceutical material comprising a purified amount of 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid. Also provided are compositions and pharmaceutical materials including a purified amount of 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid as well as methods of treating various diseases and conditions using the compositions and pharmaceutical materials.

  本发明提供了制备 8-羟基-2,2,14,14-四甲基十五烷二酸的方法和制造包含纯化量 8-羟基-2,2,14,14-四甲基十五烷二酸的药用材料的方法。还提供了包括纯化量的 8-羟基-2,2,14,14-四甲基十五烷二酸的组合物和药用材料，以及使用这些组合物和药用材料治疗各种疾病和病症的方法。
• METHODS OF MAKING BEMPEDOIC ACID AND COMPOSITIONS OF THE SAME
  申请人：Esperion Therapeutics, Inc.

  公开号：US20210139401A1

  公开（公告）日：2021-05-13

  The invention provides methods of preparing 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid and methods of making a pharmaceutical material comprising a purified amount of 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid. Also provided are compositions and pharmaceutical materials including a purified amount of 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid as well as methods of treating various diseases and conditions using the compositions and pharmaceutical materials.
• [EN] SALT FORMS OF BEMPEDOIC ACID AND METHODS FOR USING THE SAME<br/>[FR] FORMES SALINES D'ACIDE BEMPEDOÏQUE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ESPERION THERAPEUTICS INC

  公开号：WO2020257573A1

  公开（公告）日：2020-12-24

  The invention provides crystalline salt and cocrystal forms of bempedoic acid. Also provided are compositions and pharmaceutical materials including a crystalline salt or cocrystal form of bempedoic acid as well as methods of treating various diseases and conditions using the compositions and pharmaceutical materials.