2-amino-4-(3-[¹⁸F]fluoropropyl)pentanedicarboxylic acid | 1202924-29-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-amino-4-(3-[¹⁸F]fluoropropyl)pentanedicarboxylic acid
• 英文别名: 2-amino-4-(3-(18F)fluoranylpropyl)pentanedioic acid
• CAS: 1202924-29-5
• 化学式: C₈H₁₄FNO₄
• 分子量: 206.203
• InChiKey: MKDNDKMECWBLOF-RVRFMXCPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-tert-butoxycarbonylamino-4-[3-(3-trifluoromethylbenzenesulfonyloxy)propyl]pentanedioic acid di-tert-butyl ester 在 potassium carbonate 作用下， 以 水 、 乙腈 为溶剂， 生成 2-amino-4-(3-[¹⁸F]fluoropropyl)pentanedicarboxylic acid
  参考文献：
  名称：

  [EN] COMPOUNDS AND PROCESSES FOR PRODUCTION OF RADIOPHARMACEUTICALS
  [FR] COMPOSÉS ET PROCÉDÉS POUR LA PRODUCTION D'AGENTS RADIOPHARMACEUTIQUES

  摘要：

  公开号：

  WO2010000409A3

文献信息

• [Ｆ-１８]-표지된 Ｌ-글루탐산, [Ｆ-１８]-표지된 Ｌ-글루타민, 이들의 유도체 및 이들의 용도 및 이들의 제조 방법
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT 바이엘 파마 악티엔게젤샤프트(519980697332)

  公开号：KR101495924B1

  公开（公告）日：2015-02-25

  [F-18]-표지된 L-글루탐산, [F-18]-표지된 L-글루타메이트, 화학식 I에 나타낸 이들의 유도체 화합물 및 이들의 합성, 및 이들의 용도가 개시되어 있다. [F-18]-표지된 L-글루탐산 [F-18]-표지된 L-글루타메이트 유도체

  [F-18]-标记的L-谷氨酸，[F-18]-标记的L-谷氨酸盐，以及它们的衍生物化合物及其合成和用途已被介绍。 [F-18]-标记的L-谷氨酸 [F-18]-标记的L-谷氨酸盐 衍生物
• [F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION
  申请人：Dinkelborg Ludger

  公开号：US20100217011A1

  公开（公告）日：2010-08-26

  The compounds and the synthesis of [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamate, their derivatives as set forth in formula (I) and their uses are described.

  描述了[F-18]-标记的L-谷氨酸、[F-18]-标记的L-谷氨酸盐和它们的衍生物，以及它们的合成和用途。
• COMPOUNDS AND PROCESSES FOR PRODUCTION OF RADIOPHARMACEUTICALS
  申请人：Srinivasan Ananth

  公开号：US20110137063A1

  公开（公告）日：2011-06-09

  The present invention relates to novel perfluorinated precursors for the production of F-18 labeled radiotracers for Positron Emission Tomography (PET) and processes for radiolabeling and purification using these precursors. The invention also comprises radiopharmaceutical kits using these precursors and processes.

  本发明涉及一种新型的全氟化前体，用于制备正电子发射断层扫描（PET）的F-18标记放射性示踪剂，以及使用这些前体进行放射性标记和纯化的方法。本发明还包括使用这些前体和方法的放射性药物套件。
• METHODS FOR RADIATION DELIVERY IN EMISSION-GUIDED RADIOTHERAPY
  申请人：RefleXion Medical, Inc.

  公开号：US20190262630A1

  公开（公告）日：2019-08-29

  This application relates to methods for delivering radiation to a positron-emitting target within a subject under continuous PET guidance. Instead of directing radiation at a collinear path along each detected positron line-of-response (LOR), the methods generally include detecting a pattern of LORs that intersect the target. In response to the pattern, radiation may be delivered along paths that are not necessarily collinear to any of the LORs. Methods for further modifying radiation delivery as well as the detected LOR population are also described.
• [EN] METHODS FOR RADIATION DELIVERY IN EMISSION-GUIDED RADIOTHERAPY<br/>[FR] PROCÉDÉS DESTINÉS À L'ADMINISTRATION D'UN RAYONNEMENT EN RADIOTHÉRAPIE GUIDÉE PAR ÉMISSION
  申请人：REFLEXION MEDICAL INC

  公开号：WO2018093849A1

  公开（公告）日：2018-05-24

  This application relates to methods for delivering radiation to a positron-emitting target within a subject under continuous PET guidance. Instead of directing radiation at a collinear path along each detected positron line-of-response (LOR), the methods generally include detecting a pattern of LORs that intersect the target. In response to the pattern, radiation may be delivered along paths that are not necessarily collinear to any of the LORs. Methods for further modifying radiation delivery as well as the detected LOR population are also described.