4,4,6,6-pyrrolidino-3-benzyl-3,4-dihydrospiro[1.3.2]benzoxazaphosphorine[2λ5,4λ5,6λ5][1,3,5,2,4,6]triazatriphosphorine | 1236129-61-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4,6,6-pyrrolidino-3-benzyl-3,4-dihydrospiro[1.3.2]benzoxazaphosphorine[2λ5,4λ5,6λ5][1,3,5,2,4,6]triazatriphosphorine
• 英文别名: (4R)-3'-benzyl-2,2,6,6-tetrapyrrolidin-1-ylspiro[1,3,5-triaza-2lambda5,4lambda5,6lambda5-triphosphacyclohexa-1,3,5-triene-4,2'-4H-1,3,2lambda5-benzoxazaphosphinine]；(4R)-3'-benzyl-2,2,6,6-tetrapyrrolidin-1-ylspiro[1,3,5-triaza-2λ5,4λ5,6λ5-triphosphacyclohexa-1,3,5-triene-4,2'-4H-1,3,2λ5-benzoxazaphosphinine]
• CAS: 1236129-61-5
• 化学式: C₃₀H₄₅N₈OP₃
• 分子量: 626.662
• InChiKey: XQKCDYGLBDOBLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  42
• 可旋转键数：
  6
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  62.5
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 4,4,6,6-tetrachloro-3-benzyl-3,4-dihydrospiro[1.3.2]benzoxazaphosphorine[2λ5,4λ5,6λ5][1,3,5,2,4,6]triazatriphosphorine 以 四氢呋喃 为溶剂， 反应 22.0h， 以70%的产率得到4,4,6,6-pyrrolidino-3-benzyl-3,4-dihydrospiro[1.3.2]benzoxazaphosphorine[2λ5,4λ5,6λ5][1,3,5,2,4,6]triazatriphosphorine
  参考文献：
  名称：

  Phosphorus−Nitrogen Compounds. 21. Syntheses, Structural Investigations, Biological Activities, and DNA Interactions of New N/O Spirocyclic Phosphazene Derivatives. The NMR Behaviors of Chiral Phosphazenes with Stereogenic Centers upon the Addition of Chiral Solvating Agents

  摘要：

  The reactions of hexachlorocyclotriphosphazatriene, N3P3Cl6, with N/O-donor-type N-alkyl (or aryl)-o-hydroxybenzylamines (la-le) produce mono- (2a-2e), di- (3a-3d), and tri- (4a and 4b) spirocyclic phosphazenes. The tetrapyrrolidino monospirocyclic phosphazenes (2f-2i) are prepared from the reactions of partly substituted compounds (2a-2d) with excess pyrrolidine. The dispirodipyrrolidinophosphazenes (3e-3h) and trispirophosphazenes (3i-3k) are obtained from the reactions of trans-dispirophosphazenes with excess pyrrolidine and sodium (3-amino-1-propanoxide), respectively. Compounds 3a-3d have cis and trans geometric isomers. Only the trans isomers of these compounds are isolated. Compounds 3a-3h have two stereogenic P atoms. They are expected to be in cis (meso) and trans (racemic) geometric isomers. In the trans trispiro compounds (3i-3k), there are three stereogenic P atoms. They are expected to be in racemic mixtures. The stereogenic properties of 3a-3k are confirmed by P-31 NMR spectroscopy upon the addition of the chiral solvating agent; (S)-(+)-2,2,2-trifluoro-1-(9'-anthryl)ethanol. The molecular structures of 3i-3k, 4a, and 4b look similar to a propeller, where the chemical environment of one P atom is different from that of others. Additionally, 4a and 4b are also expected to exist as cis-trans-trans and cis-cis-cis geometric isomers, but both of them are found to be in cis-trans-trans geometries. The solid-state structures of 2a, 2e, 2f, 3e, and 31 are determined by X-ray crystallography. The compounds 2f-2i, 3e-3i, and 3k are screened for antibacterial activity against Gram-positive and Gram-negative bacteria and for antifungal activity against yeast strains. These compounds (except 3f) have shown a strong affinity against most of the bacteria. Minimum inhibitory concentrations (MIC) are determined for 2f-2i, 3e-3i, and 3k. DNA binding and the nature of interaction with pUC18 plasmid DNA are studied. The compounds 2f-2i, 3e-3i, and 3k induce changes on the DNA mobility. The prevention of BamHI and HindIII digestion (except 2g) with compounds indicates that the compounds bind with nucleotides in DNA.

  DOI：

  10.1021/ic100781v