(3E)-6,6-bis(benzenesulfonyl)-3-benzylidene-4-methylidene-2,4a,5,7-tetrahydro-1H-naphthalene | 1001160-21-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3E)-6,6-bis(benzenesulfonyl)-3-benzylidene-4-methylidene-2,4a,5,7-tetrahydro-1H-naphthalene
• CAS: 1001160-21-9
• 化学式: C₃₀H₂₈O₄S₂
• 分子量: 516.682
• InChiKey: IBVVGOKGFUVASG-YYADALCUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  85
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-苯基马来酰亚胺 、 (3E)-6,6-bis(benzenesulfonyl)-3-benzylidene-4-methylidene-2,4a,5,7-tetrahydro-1H-naphthalene 以 甲苯 为溶剂， 反应 13.0h， 生成 、 (7R,7aR,10aS,11bR)-2,2-bis(benzenesulfonyl)-7,9-diphenyl-3,5,6,7,7a,10a,11,11b-octahydro-1H-naphtho[1,2-f]isoindole-8,10-dione
  参考文献：
  名称：

  Rh-Catalyzed Triple Allene Approach to Bicyclo[4.4.0]decene Derivatives and Its Application for the Stepwise Synthesis of Steroid-Like Tetracyclic Skeletons

  摘要：

  The construction of a new type of bicyclo[4.4.0]decene products with a conjugated exocyclic diene unit was developed using Rh-catalyzed cyclization of 1,5-bisallenes in the presence of monoallenes. The steroid-like tetracyclic products could be obtained by applying an alkylation-Diels-Alder process.

  DOI：

  10.1021/ol702557s
• 作为产物：
  描述：

  5,5-bis(phenylsulfonyl)-1,2,7,8-nonatetraene 、 丙-1,2-二烯基苯 在 trans-RhCl(CO)(PPh₃)2 作用下， 以 甲苯 为溶剂， 反应 22.0h， 以55%的产率得到(3E)-6,6-bis(benzenesulfonyl)-3-benzylidene-4-methylidene-2,4a,5,7-tetrahydro-1H-naphthalene
  参考文献：
  名称：

  Rh-Catalyzed Triple Allene Approach to Bicyclo[4.4.0]decene Derivatives and Its Application for the Stepwise Synthesis of Steroid-Like Tetracyclic Skeletons

  摘要：

  The construction of a new type of bicyclo[4.4.0]decene products with a conjugated exocyclic diene unit was developed using Rh-catalyzed cyclization of 1,5-bisallenes in the presence of monoallenes. The steroid-like tetracyclic products could be obtained by applying an alkylation-Diels-Alder process.

  DOI：

  10.1021/ol702557s

文献信息

• Rh-Catalyzed Triple Allene Approach to Bicyclo[4.4.0]decene Derivatives and Its Application for the Stepwise Synthesis of Steroid-Like Tetracyclic Skeletons
  作者：Ping Lu、Shengming Ma

  DOI：10.1021/ol702557s

  日期：2007.12.1

  The construction of a new type of bicyclo[4.4.0]decene products with a conjugated exocyclic diene unit was developed using Rh-catalyzed cyclization of 1,5-bisallenes in the presence of monoallenes. The steroid-like tetracyclic products could be obtained by applying an alkylation-Diels-Alder process.