1-[4-oxo-6-(3-trifluoromethyl-phenoxy)-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid | 1238691-03-6

• 分子结构分类: 有机化合物
• 英文名称: 1-[4-oxo-6-(3-trifluoromethyl-phenoxy)-3,4-dihydro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid
• 英文别名: 1-[4-oxo-6-[3-(trifluoromethyl)phenoxy]-3H-quinazolin-2-yl]pyrazole-4-carboxylic acid
• CAS: 1238691-03-6
• 化学式: C₁₉H₁₁F₃N₄O₄
• 分子量: 416.316
• InChiKey: UBIKFWDVLAPYBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS
  申请人：Bembenek Scott D.

  公开号：US20100204226A1

  公开（公告）日：2010-08-12

  Quinazolinone compounds of formula (I) are described, which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by prolyl hydroxylase activity. Thus, the compounds may be administered to treat, e.g., anemia, vascular disorders, metabolic disorders, and wound healing.

  公式（I）的喹唑啉酮化合物被描述为脯氨酸羟化酶抑制剂，这些化合物可用于制药组合物和治疗由脯氨酸羟化酶活性介导的疾病状态、紊乱和情况的方法。因此，这些化合物可用于治疗贫血、血管紊乱、代谢紊乱和伤口愈合等疾病。
• US8937078B2
  申请人：——

  公开号：US8937078B2

  公开（公告）日：2015-01-20
• [EN] QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS<br/>[FR] QUINAZOLINONES EN TANT QU'INHIBITEURS DE PROLYLE HYDROXYLASE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2010093727A1

  公开（公告）日：2010-08-19

  Quinazolinone compounds of formula (I) are described, which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by prolyl hydroxylase activity. Thus, the compounds may be administered to treat, e.g., anemia, vascular disorders, metabolic disorders, and wound healing.