| 99564-27-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 99564-27-9
• 化学式: C₂₃H₄₅N₂O₃
• 分子量: 397.622
• InChiKey: HXPKRMMVVQWIJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  28
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  53.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2R)-2-amino-4-{[(3S)-3-amino-4-methoxy-4-oxobutyl]disulfanyl}butanoic acid methyl ester 、 在 2-乙氧基-1-乙氧碳酰基-1,2-二氢喹啉 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以50%的产率得到
  参考文献：
  名称：

  Amphiphilic spin probes based on disulfide-bridged bisnitroxides

  摘要：

  We have synthesised a series of amphiphilic spin probes containing two nitroxide-functionalised lipophilic branches connected by a disulfide group. The sensitivity of EPR spectroscopy to the interactions between the radical centres in these bisnitroxides makes it possible to monitor the thiol-disulfide exchange reaction in colloidal assemblies. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.07.131
• 作为产物：
  描述：

  在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以95%的产率得到
  参考文献：
  名称：

  Amphiphilic spin probes based on disulfide-bridged bisnitroxides

  摘要：

  We have synthesised a series of amphiphilic spin probes containing two nitroxide-functionalised lipophilic branches connected by a disulfide group. The sensitivity of EPR spectroscopy to the interactions between the radical centres in these bisnitroxides makes it possible to monitor the thiol-disulfide exchange reaction in colloidal assemblies. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.07.131

文献信息

• Amphiphilic spin probes based on disulfide-bridged bisnitroxides
  作者：Riccardo Garzelli、Vadim K. Khlestkin、Nicholas H. Williams、Victor Chechik

  DOI：10.1016/j.tetlet.2008.07.131

  日期：2008.10

  We have synthesised a series of amphiphilic spin probes containing two nitroxide-functionalised lipophilic branches connected by a disulfide group. The sensitivity of EPR spectroscopy to the interactions between the radical centres in these bisnitroxides makes it possible to monitor the thiol-disulfide exchange reaction in colloidal assemblies. (C) 2008 Elsevier Ltd. All rights reserved.