Methyl 2-(7-methoxy-4,5-dihydrobenzo[g][2]benzofuran-1-yl)acetate | 1201697-75-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: Methyl 2-(7-methoxy-4,5-dihydrobenzo[g][2]benzofuran-1-yl)acetate
• 英文别名: methyl 2-(7-methoxy-4,5-dihydrobenzo[g][2]benzofuran-1-yl)acetate
• CAS: 1201697-75-7
• 化学式: C₁₆H₁₆O₄
• 分子量: 272.301
• InChiKey: MTUBHJSDBQWDRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  48.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-(2-formyl-6-methoxy-3,4-dihydro-naphthalen-1-yl)acrylic acid methyl ester 在 potassium carbonate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 以70%的产率得到Methyl 2-(7-methoxy-4,5-dihydrobenzo[g][2]benzofuran-1-yl)acetate
  参考文献：
  名称：

  Sodium borohydride or potassium carbonate-mediated intramolecular Michael addition: a general method for the synthesis of fused dihydrofuran and furan derivatives

  摘要：

  A simple and convenient method for the synthesis of fused dihydrofuran derivatives using NaBH4-mediated reductive cyclization and fused furan derivatives by K2CO3-mediated intramolecular Michael addition followed by acid-catalyzed methanol elimination has been developed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.09.071

文献信息

• Sodium borohydride or potassium carbonate-mediated intramolecular Michael addition: a general method for the synthesis of fused dihydrofuran and furan derivatives
  作者：Shubhankar Samanta、Rathin Jana、Jayanta K. Ray

  DOI：10.1016/j.tetlet.2009.09.071

  日期：2009.12

  A simple and convenient method for the synthesis of fused dihydrofuran derivatives using NaBH4-mediated reductive cyclization and fused furan derivatives by K2CO3-mediated intramolecular Michael addition followed by acid-catalyzed methanol elimination has been developed. (C) 2009 Elsevier Ltd. All rights reserved.