5-Diphenylphosphoryl-2-methoxybenzonitrile | 1404477-04-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Diphenylphosphoryl-2-methoxybenzonitrile
• 英文别名: 5-diphenylphosphoryl-2-methoxybenzonitrile
• CAS: 1404477-04-8
• 化学式: C₂₀H₁₆NO₂P
• 分子量: 333.326
• InChiKey: ATLRZAOLXAMGIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-Diphenylphosphoryl-2-methoxybenzonitrile 在 甲基二乙氧基硅烷 、 双(对硝基苯基)磷酸酯 作用下， 以 甲苯 为溶剂， 以90%的产率得到5-(diphenylphosphino)-2-methoxybenzonitrile
  参考文献：
  名称：

  Highly Chemoselective Metal-Free Reduction of Phosphine Oxides to Phosphines

  摘要：

  Unprecedented chemoselective reductions of phosphine oxides to phosphines proceed smoothly in the presence of catalytic amounts of specific Bronsted acids. By utilizing inexpensive silanes, e.g., PMHS or (EtO)(2)MeSiH, other reducible functional groups such as ketones, aldehydes, olefins, nitriles, and esters are well-tolerated under optimized conditions.

  DOI：

  10.1021/ja3069165

文献信息

• Highly Chemoselective Metal-Free Reduction of Phosphine Oxides to Phosphines
  作者：Yuehui Li、Liang-Qiu Lu、Shoubhik Das、Sabine Pisiewicz、Kathrin Junge、Matthias Beller

  DOI：10.1021/ja3069165

  日期：2012.11.7

  Unprecedented chemoselective reductions of phosphine oxides to phosphines proceed smoothly in the presence of catalytic amounts of specific Bronsted acids. By utilizing inexpensive silanes, e.g., PMHS or (EtO)(2)MeSiH, other reducible functional groups such as ketones, aldehydes, olefins, nitriles, and esters are well-tolerated under optimized conditions.