(5-(tert-butyldimethylsilyloxy)-1,3-phenylene)dimethanamine | 1206156-37-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5-(tert-butyldimethylsilyloxy)-1,3-phenylene)dimethanamine
• 英文别名: [3-(Aminomethyl)-5-[tert-butyl(dimethyl)silyl]oxyphenyl]methanamine；[3-(aminomethyl)-5-[tert-butyl(dimethyl)silyl]oxyphenyl]methanamine
• CAS: 1206156-37-7
• 化学式: C₁₄H₂₆N₂OSi
• 分子量: 266.459
• InChiKey: SXGCOFZTUANRBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.99
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  61.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (5-(tert-butyldimethylsilyloxy)-1,3-phenylene)dimethanamine 、 2,5-dioxopyrrolidin-1-yl 5-(butylcarbamoyl)-1Hpyrrole-2-carboxylate 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 19.0h， 以64%的产率得到N2,N2'-(5-(tert-butyldimethylsilyloxy)-1,3-phenylene) bis(methylene)bis(N5-butyl-1H-pyrrole-2,5-dicarboxamide)
  参考文献：
  名称：

  Fluorescent receptor for dicarboxylates based on pyrrolecarboxamides

  摘要：

  Neutral ditopic and fluorescent receptor 1 based on two 2,5-pyrrolecarboxamide units shows a strong association with dicarboxylate anions such as glutarate and adipate through multiple hydrogen bonds. Fluorescence and H-1 NMR titrations display a 1: 1 stoichiometry for the complexes, with glutarate as the most strongly bound guest. Receptor 1 exhibits PET-induced fluorescence quenching upon recognition due to the presence of a dansyl group. The synthetic methodology described here might provide access to closely related receptors by the introduction of different fluorophores in the last step of the synthesis.

  DOI：

  10.1080/10610278.2012.671523
• 作为产物：
  描述：

  2,2'-(5-(tert-butyldimethylsilyloxy)-1,3-phenylene)bis(methylene)diisoindoline-1,3-dione 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以56%的产率得到(5-(tert-butyldimethylsilyloxy)-1,3-phenylene)dimethanamine
  参考文献：
  名称：

  Fluorescent receptor for dicarboxylates based on pyrrolecarboxamides

  摘要：

  Neutral ditopic and fluorescent receptor 1 based on two 2,5-pyrrolecarboxamide units shows a strong association with dicarboxylate anions such as glutarate and adipate through multiple hydrogen bonds. Fluorescence and H-1 NMR titrations display a 1: 1 stoichiometry for the complexes, with glutarate as the most strongly bound guest. Receptor 1 exhibits PET-induced fluorescence quenching upon recognition due to the presence of a dansyl group. The synthetic methodology described here might provide access to closely related receptors by the introduction of different fluorophores in the last step of the synthesis.

  DOI：

  10.1080/10610278.2012.671523