2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrate | 1185726-82-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrate
• 英文别名: 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol;hydrate
• CAS: 1185726-82-2
• 化学式: C16H27NO3
• 分子量: 281.39
• InChiKey: AMSRVIPLTBYHPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.81
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  33.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Process for preparing tramadol hydrochloride and/or tramadol monohydrate
  申请人：Jubilant Organosys Limited

  公开号：EP1346978A1

  公开（公告）日：2003-09-24

  A process is described for the preparation of (RR,SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol hydrochloride (hereinafter 'tramadol hydrochloride'), which process comprises reacting an intermediate comprising one or more of: (a) a mixture of (RR,SS)- and (RS,SR)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol; and/or (b) a hydrate of (RR,SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol; with HCl in the presence of a catalytic amount of water. The process can be carried out in the absence of 1,4-dioxane or other category 1 carcinogenic solvent, and in one step, providing commercial advantages of simplicity, safety and purity. Tramadol hydrochloride is a known non-narcotic analgesic.

  本发明描述了一种制备(RR,SS)-2-二甲基氨基甲基-1-(3-甲氧基苯基)环己醇盐酸盐（以下简称 "盐酸曲马多"）的工艺，该工艺包括使包含以下物质中的一种或多种的中间体发生反应： (a) (RR,SS)-和(RS,SR)-2-二甲基氨基甲基-1-(3-甲氧基苯基)环己醇的混合物；和/或 (b) (RR,SS)-2-二甲基氨基甲基-1-(3-甲氧基苯基)环己醇的水合物； 在一定量的水催化下与盐酸反应。 该工艺可在不使用 1,4-二恶烷或其他 1 类致癌溶剂的情况下一步完成，具有简单、安全和纯度高等商业优势。盐酸曲马多是一种已知的非麻醉性镇痛药。
• BIOMEDIATED-TITANIUM NANOCOMPOSITE FOR CORROSION PROTECTION
  申请人：King Fahd University of Petroleum and Minerals

  公开号：US20200255734A1

  公开（公告）日：2020-08-13

  The present invention relates to a method of inhibiting corrosion of steel in contact with a corrosive solution. The method involves mixing an olive leaf extract titanium nanocomposite with the corrosive solution. The olive leaf extract titanium nanocomposite may be made by reducing TiCl 4 with an olive leaf extract, which forms nanoparticles with an average size of 50-100 nm.
• [EN] PROCESS FOR PREPARING TRAMADOL HYDROCHLORIDE AND/OR TRAMADOL MOMOHYDRATE<br/>[FR] PROCEDE DE PREPARATION DE CHLORHYDRATE DE TRAMADOL ET/OU DE MONOHYDRATE DE TRAMADOL
  申请人：MAX INDIA LTD

  公开号：WO2003078380A2

  公开（公告）日：2003-09-25

  A process is described for the preparation of (RR,SS~2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol hydrochloride (hereinafter 'tramadol hydrochloride'), which process comprises reacting a mixture of (RR,SS)- and (RS,SR)-2-dimethylaminomethyl-l-(3-methoxyphenyl) cyclohexanol with HCI in the presence of a catalytic amount of water. The process can be carried out in the absence of 1,4-dioxane or other category 1 carcinogenic solvent, and in one step, providing commercial advantages of simplicity, safety and purity. Tramadolhydrochloride is a known non-narcotic analgesic.