1,1,3,3-tetramethyl-4-oxo-6-phenyl-1,2,3,4-tetrahydropyrano[3,4-c]pyrrol-2-oxyl | 1422058-69-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 1,1,3,3-tetramethyl-4-oxo-6-phenyl-1,2,3,4-tetrahydropyrano[3,4-c]pyrrol-2-oxyl
• CAS: 1422058-69-2
• 化学式: C₁₇H₁₈NO₃
• 分子量: 284.335
• InChiKey: XVPZZIKTSSVUOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  30.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,2,5,5-tetramethyl-4-phenylethynyl-2,5-dihydro-1H-pyrrole-3-carbaldehyde-1-yloxyl radical 在 gold(III) chloride 、 sodium chlorite 、 potassium dihydrogenphosphate 、 双氧水 作用下， 以 水 、 乙腈 为溶剂， 反应 1.5h， 生成 1,1,3,3-tetramethyl-4-oxo-6-phenyl-1,2,3,4-tetrahydropyrano[3,4-c]pyrrol-2-oxyl
  参考文献：
  名称：

  Synthesis of Nitroxide-Annulated Carbocycles and Heterocycles

  摘要：

  New, pyrroline nitroxide annulated lactones, polycycles, and maleimide were synthesized by classical and microwave-assisted methodology. We report the application of the metathesis reaction in the presence of nitroxide yielding a pyrroline nitroxide condensed 1,4-benzoquinone as a paramagnetic dienophile. The formation of the isoselenazolone-fused pyrroline ring system was examined and different reactivity was observed with pyrrolin-1-oxyl and pyrroline derivatives.

  DOI：

  10.1055/s-0032-1317516

文献信息

• Synthesis of Nitroxide-Annulated Carbocycles and Heterocycles
  作者：Kálmán Hideg、Tamás Kálai、Balázs Bognár、Dániel Zsolnai、Zoltán Berente

  DOI：10.1055/s-0032-1317516

  日期：——

  New, pyrroline nitroxide annulated lactones, polycycles, and maleimide were synthesized by classical and microwave-assisted methodology. We report the application of the metathesis reaction in the presence of nitroxide yielding a pyrroline nitroxide condensed 1,4-benzoquinone as a paramagnetic dienophile. The formation of the isoselenazolone-fused pyrroline ring system was examined and different reactivity was observed with pyrrolin-1-oxyl and pyrroline derivatives.