4,7-Diazaspiro[2.5]octan-8-one | 907973-01-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4,7-Diazaspiro[2.5]octan-8-one
• CAS: 907973-01-7
• 化学式: C₆H₁₀N₂O
• mdl: MFCD07373478
• 分子量: 126.16
• InChiKey: FSLZGHJDIDSIPF-UHFFFAOYSA-N

物化性质

• 沸点：
  349.8±35.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES
  申请人：MUTHUPPALANIAPPAN Meyyappan

  公开号：US20110281865A1

  公开（公告）日：2011-11-17

  The present invention provides, inter alia, compounds of formula I as protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

  本发明提供了一种公式I的化合物作为蛋白激酶调节剂，以及它们的制备方法、含有它们的药物组合物，以及利用它们治疗、预防和/或改善激酶介导的疾病或紊乱的方法。
• [EN] DIAZASPIROALKANEONE-SUBSTITUTED OXAZOLE DERIVATIVES AS SPLEEN TYROSINE KINASE INHIBITORS<br/>[FR] DÉRIVÉS D'OXAZOLE À SUBSTITUANT DIAZASPIROALCANONE EN TANT QU'INHIBITEURS DE LA TYROSINE KINASE SPLÉNIQUE
  申请人：AB SCIENCE

  公开号：WO2015144614A1

  公开（公告）日：2015-10-01

  The present invention is concerned with diazaspiroalkanone- substituted oxazole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, autoimmune, allergic, and degenerative disorders. In particular, the presently disclosed compounds are Syk inhibitors.

  本发明涉及替代噻唑衍生物的二氮杂螺环戊酮，能够选择性地调节、调控和/或抑制由某些与多种人类和动物疾病相关的天然和/或突变的蛋白激酶介导的信号传导，例如细胞增殖、代谢、自身免疫、过敏和退行性疾病。特别是，目前披露的化合物是Syk抑制剂。
• NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5-DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES
  申请人：Rhizen Pharmaceuticals SA

  公开号：US20130261116A1

  公开（公告）日：2013-10-03

  The present invention provides, inter alia, compounds of formula I as protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

  本发明提供了一些公式I化合物作为蛋白激酶调节剂，它们的制备方法，包含它们的制药组合物，以及使用它们进行激酶介导的疾病或障碍的治疗、预防和/或改善的方法。
• Diazaspiroalkaneone-substituted oxazole derivatives as spleen tyrosine kinase inhibitors
  申请人：AB SCIENCE

  公开号：US10053455B2

  公开（公告）日：2018-08-21

  The present invention is concerned with substituted oxazole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, autoimmune, allergic, and degenerative disorders. In particular, the presently disclosed compounds are Syk inhibitors.

  本发明涉及取代的噁唑衍生物，这些衍生物可选择性地调节、调节和/或抑制由某些原生和/或突变蛋白激酶介导的信号转导，这些蛋白激酶与多种人类和动物疾病有关，如细胞增殖性疾病、代谢性疾病、自身免疫性疾病、过敏性疾病和退行性疾病。特别是，目前公开的化合物是 Syk 抑制剂。
• DIAZASPIROALKANEONE-SUBSTITUTED OXAZOLE DERIVATIVES AS SPLEEN TYROSINE KINASE INHIBITORS
  申请人：AB Science

  公开号：EP3122744A1

  公开（公告）日：2017-02-01