1-(3,5-di-O-benzyl-2-O,4-C-methylene-β-D-ribofuranosyl)-4-(3-nitrophenyl)-2-pyridone | 1029931-16-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-(3,5-di-O-benzyl-2-O,4-C-methylene-β-D-ribofuranosyl)-4-(3-nitrophenyl)-2-pyridone
• CAS: 1029931-16-5
• 化学式: C₃₁H₂₈N₂O₇
• 分子量: 540.573
• InChiKey: KQBMPYKSCIEFAU-ITGKQZKFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.89
• 重原子数：
  40.0
• 可旋转键数：
  10.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  102.06
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  1-(3,5-di-O-benzyl-2-O,4-C-methylene-β-D-ribofuranosyl)-4-(3-nitrophenyl)-2-pyridone 在 platinum(IV) oxide 氢气 作用下， 以 乙醇 、 乙酸乙酯 为溶剂， 反应 18.0h， 以100%的产率得到4-(3-aminophenyl)-1-(3,5-di-O-benzyl-2-O,4-C-methylene-β-D-ribofuranosyl)-2-pyridone
  参考文献：
  名称：

  Recognition of T·A interruption by 2′,4′-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation

  摘要：

  2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) monomers bearing novel unnatural nucleobases, 4-(3-benzamidophenyl)-2-pyridone and 2-(N-methylbenzamido)thiazole, were synthesized and successfully incorporated into oligonucleotides. UV melting experiments showed that the corresponding oligonucleotide derivatives formed stable triplexes with dsDNA targets even in the presence of a T center dot A interruption. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.12.043
• 作为产物：
  描述：

  1-(3,5-di-O-benzyl-2-O,4-C-methylene-β-D-ribofuranosyl)-4-p-toluenesulfonyloxy-2-pyridone 、 3-硝基苯硼酸 在 四(三苯基膦)钯 potassium phosphate 、 potassium bromide 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以64%的产率得到1-(3,5-di-O-benzyl-2-O,4-C-methylene-β-D-ribofuranosyl)-4-(3-nitrophenyl)-2-pyridone
  参考文献：
  名称：

  Recognition of T·A interruption by 2′,4′-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation

  摘要：

  2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) monomers bearing novel unnatural nucleobases, 4-(3-benzamidophenyl)-2-pyridone and 2-(N-methylbenzamido)thiazole, were synthesized and successfully incorporated into oligonucleotides. UV melting experiments showed that the corresponding oligonucleotide derivatives formed stable triplexes with dsDNA targets even in the presence of a T center dot A interruption. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.12.043