ethyl 4-oxo-4,6,7,8-tetrahydropyrrolo[2,1-c][1,2,4]triazine-3-carboxylate | 1134780-38-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并三嗪类
• 英文名称: ethyl 4-oxo-4,6,7,8-tetrahydropyrrolo[2,1-c][1,2,4]triazine-3-carboxylate
• 英文别名: ethyl 4-oxo-7,8-dihydro-6H-pyrrolo[2,1-c][1,2,4]triazine-3-carboxylate
• CAS: 1134780-38-3
• 化学式: C₉H₁₁N₃O₃
• 分子量: 209.205
• InChiKey: UMZJQANARPHTQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  71.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-diazo-3-(2-oxopyrrolidin-1-yl)-3-oxopropionic acid ethyl ester 在 三苯基膦 作用下， 以 水 为溶剂， 反应 1.5h， 以95%的产率得到ethyl 4-oxo-4,6,7,8-tetrahydropyrrolo[2,1-c][1,2,4]triazine-3-carboxylate
  参考文献：
  名称：

  PPh3-mediated reactions of diazoimides in water: a facile synthesis of fused triazine derivatives

  摘要：

  Triphenylphosphine-mediated reactions of diazoimides in water were carried out under mild conditions to afford several triazine derivatives in high yields. We have demonstrated an environment friendly methodology to synthesize triazine derivatives. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.01.021

文献信息

• PPh3-mediated reactions of diazoimides in water: a facile synthesis of fused triazine derivatives
  作者：Sengodagounder Muthusamy、Pandurangan Srinivasan

  DOI：10.1016/j.tetlet.2009.01.021

  日期：2009.3

  Triphenylphosphine-mediated reactions of diazoimides in water were carried out under mild conditions to afford several triazine derivatives in high yields. We have demonstrated an environment friendly methodology to synthesize triazine derivatives. (C) 2009 Elsevier Ltd. All rights reserved.