(1S,2R,3R)-3-(benzyloxymethyl)-1-<5-methyl-(1S)-hydroxyhexyl>-2-(tosyloxymethyl) cyclopentane | 166045-86-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1S,2R,3R)-3-(benzyloxymethyl)-1-<5-methyl-(1S)-hydroxyhexyl>-2-(tosyloxymethyl) cyclopentane
• CAS: 166045-86-9
• 化学式: C₂₈H₄₀O₅S
• 分子量: 488.689
• InChiKey: NGKBMWKIBBHPSY-VNNZRSTGSA-N

反应信息

• 作为反应物：
  描述：

  (1S,2R,3R)-3-(benzyloxymethyl)-1-<5-methyl-(1S)-hydroxyhexyl>-2-(tosyloxymethyl) cyclopentane 在 sodium hydride 作用下， 以 乙二醇二甲醚 为溶剂， 反应 6.0h， 以83%的产率得到(1S,2S,3R,4R)-4-(benzyloxymethyl)-1-(4-methylpentyl)-hexahydro-cyclopentafuran
  参考文献：
  名称：

  1,2-Induction in intramolecular diene cyclozirconation: Control of relative configuration

  摘要：

  We have observed that cyclozirconation of a diene having a substituent on the bridge connecting the two alkenes leads to a single predominant zirconacycle with control of three new stereogenic centers.

  DOI：

  10.1016/0040-4020(94)01136-n
• 作为产物：
  描述：

  对甲苯磺酰氯 、 (1S,2R,3R)-3-(benzyloxymethyl)-2-(hydroxymethyl)-1-<5-methyl-hydroxyhexyl>-cyclopentane 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 3.5h， 以57%的产率得到(1S,2R,3R)-3-(benzyloxymethyl)-1-<5-methyl-(1S)-hydroxyhexyl>-2-(tosyloxymethyl) cyclopentane
  参考文献：
  名称：

  1,2-Induction in intramolecular diene cyclozirconation: Control of relative configuration

  摘要：

  We have observed that cyclozirconation of a diene having a substituent on the bridge connecting the two alkenes leads to a single predominant zirconacycle with control of three new stereogenic centers.

  DOI：

  10.1016/0040-4020(94)01136-n