γ,γ'-Diacetoxyisovaleriansaeure | 63166-02-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: γ,γ'-Diacetoxyisovaleriansaeure
• 英文别名: 4-Acetoxy-3-acetoxymethyl-butyric acid；4-acetyloxy-3-(acetyloxymethyl)butanoic acid
• CAS: 63166-02-9
• 化学式: C₉H₁₄O₆
• 分子量: 218.207
• InChiKey: LIANOBXIDJHRSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  二氢-2H-吡喃-4(3h)-酮 肟 、 Bis(4-acetoxy-3-acetoxymethyl-butyrate) iodobenzene 生成 、 γ,γ'-Diacetoxyisovaleriansaeure
  参考文献：
  名称：

  NOVEL NITROSO COMPOUNDS AS NITROXYL DONORS AND METHODS OF USE THEREOF

  摘要：

  本发明涉及一种亚硝基衍生物，包括羧酸和磷酸酯的羟基亚硝基化合物，其在生理条件下捐赠亚硝基（HNO）。本发明的化合物和组合物对于治疗和/或预防对亚硝基疗法有反应的疾病或病症的发作和/或发展，包括心力衰竭，缺血/再灌注损伤和癌症具有用处。

  公开号：

  US20160052862A1

文献信息

• Stable Enzymatic Peracid Generating Systems
  申请人：Barnett Christopher C.

  公开号：US20100189707A1

  公开（公告）日：2010-07-29

  The present invention provides stable compositions comprising a perhydrolase enzyme, a hydrogen peroxide source, and an ester substrate that efficiently generate aqueous peracid solutions. The generated peracid solutions are suitable for decontaminating and/or sanitizing a wide range of materials and equipment contaminated with pathogens or toxic chemicals. In one preferred embodiment, the stable composition comprises an acyl transferase enzyme, sodium percarbonate, and propylene glycol diacetate, and is stable for 30 days or longer. Upon addition to water, the composition is activated and generates an aqueous solution with a high ratio of peracetic acid to acetic acid.

  本发明提供了一种稳定的组合物，包括一种过氧化酶酶、一种过氧化氢源和一种酯基底物，能够高效地生成水性过酸溶液。生成的过酸溶液适用于对被病原体或有毒化学物质污染的各种材料和设备进行脱污和/或消毒。在一个优选实施例中，稳定的组合物包括一种酰基转移酶酶、过碳酸钠和丙二醇二乙酸丙酯，并且稳定时间为30天或更长。加入水后，该组合物被激活并生成一个高比例的过乙酸与乙酸的水性溶液。
• Nitroso compounds as nitroxyl donors and methods of use thereof
  申请人：Cardioxyl Pharmaceuticals, Inc.

  公开号：US08318705B2

  公开（公告）日：2012-11-27

  The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.

  本发明涉及一种亚硝基衍生物，包括羧酸和磷酸酯化的羟基亚硝基化合物，在生理条件下捐赠亚硝基（HNO）。本发明的化合物和组合物在治疗和/或预防对亚硝基治疗有反应的疾病或病状的发生和/或发展方面有用，包括心衰、缺血/再灌注损伤和癌症。
• Novel Nitroso Compounds as Nitroxyl Donors and Methods of Use Thereof
  申请人：CARDIOXYL PHARMACEUTICALS, INC.

  公开号：US20130045951A1

  公开（公告）日：2013-02-21

  The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.

  本发明涉及一种亚硝基衍生物，包括羧酸和磷酸酯的羟基亚硝基化合物，可在生理条件下捐赠亚硝基（HNO）。该发明的化合物和组合物在治疗和/或预防对亚硝基疗法有反应的疾病或状况的发生和/或发展方面是有用的，包括心衰、缺血/再灌注损伤和癌症。
• Photographic material and process for retouching dye images
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0438825A1

  公开（公告）日：1991-07-31

  A method of retouching a dye image comprises selective removal with an aqueous acidic organic solvent solution of a portion of a dye image from an exposed and processed photographic silver halide element comprising a support bearing a dye image from a dye-forming coupler and a primary amine photographic color developing agent, wherein the dye-forming coupler: (a) contains no ionizable group that is retained as part of a dye formed upon oxidative coupling, (b) has a structure such that its octanol/water partition coefficient, P, has a value such that Log P of the coupler is greater than 4 and is derived from a four-equivalent coupler that has a Log P less than 8, and (c) has a coupling reactivity that enables formation of maximum image density of at least 0.6. The method comprises the step of contacting the dye image with an aqueous acidic organic solvent solution for a time and at a temperature sufficient to selectively dissolve and remove a portion of the dye image from the photographic element. A new photographic element designed for such retouching comprises new pyrazolotriazole couplers.

  一种修饰染料图像的方法，包括用酸性有机溶剂水溶液选择性地去除已曝光和处理过的照相卤化银元件上的部分染料图像，该元件包括承载染料图像的支座，染料形成耦合剂和伯胺照相显色剂，其中染料形成耦合剂：(a) 不含有在氧化偶联时作为染料的一部分保留下来的可电离基团， (b) 具有这样的结构，即其辛醇/水分配系数 P 具有这样的值，即该偶联剂的对数 P 大于 4，并且是从对数 P 小于 8 的四当量偶联剂衍生而来，以及 (c) 具有这样的偶联反应性，即能够形成至少 0.5%的最大图像密度。6.该方法包括以下步骤：将染料图像与酸性有机溶剂水溶液接触，接触时间和温度足以选择性地溶解并从感光元件中去除部分染料图像。为这种修饰而设计的新型感光元件包括新型吡唑三唑偶联剂。
• CYCLOSPORINE A TOPICAL COMPOSITIONS
  申请人：Spherium Biomed S.L.

  公开号：EP3187172A1

  公开（公告）日：2017-07-05

  The present invention relates to topical pharmaceutical microemulsions of cyclosporine A comprising a half (C1-C4) alkyl esters of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) copolymers. The invention also relates to a process for the preparation of said compositions and to their use in the prevention and/or treatment of several diseases, particularly psoriasis and atopic dermatitis.

  本发明涉及由聚（甲基乙烯基醚-共马来酸酐）（PVM/MA）共聚物的半（C1-C4）烷基酯组成的环孢素 A 局部药用微乳剂。本发明还涉及制备上述组合物的工艺及其在预防和/或治疗多种疾病，特别是银屑病和特应性皮炎中的用途。