2-[(4-Oxo-4-phenylmethoxybutanoyl)-(2-tetradecanoyloxyethyl)amino]ethyl tetradecanoate | 1402925-50-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(4-Oxo-4-phenylmethoxybutanoyl)-(2-tetradecanoyloxyethyl)amino]ethyl tetradecanoate
• 英文别名: 2-[(4-oxo-4-phenylmethoxybutanoyl)-(2-tetradecanoyloxyethyl)amino]ethyl tetradecanoate
• CAS: 1402925-50-1
• 化学式: C₄₃H₇₃NO₇
• 分子量: 716.055
• InChiKey: CSXGTBQNNZQFBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.2
• 重原子数：
  51
• 可旋转键数：
  38
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  99.2
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-[(4-Oxo-4-phenylmethoxybutanoyl)-(2-tetradecanoyloxyethyl)amino]ethyl tetradecanoate 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 8.0h， 以99%的产率得到4-(bis(2-(tetradecanoyloxy)ethyl)amino)-4-oxobutanoic acid
  参考文献：
  名称：

  Synthesis, Antibacterial Activity and Cytotoxicity of Novel Janus Peptide Dendrimers

  摘要：

  In an attempt to find new antibacterial agents, a series of well-defined Janus peptide dendrimers, which feature multiple anionic groups and amphiphilic structure, were synthesized and characterized in detail. The antibacterial activities of all the synthesized dendrimers were tested and screened by using the two-fold serial dilution method. Several compounds showed activity against E. coli, S. aureus, methicillin-resistant S. aureus, and E. faecalis. Further cytotoxicity assays showed that the antibacterial dendrimers were nontoxic against HEK293.

  DOI：

  10.1055/s-0031-1290403
• 作为产物：
  描述：

  Benzyl 4-[bis(2-hydroxyethyl)amino]-4-oxobutanoate 、 肉豆蔻酸 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以82%的产率得到2-[(4-Oxo-4-phenylmethoxybutanoyl)-(2-tetradecanoyloxyethyl)amino]ethyl tetradecanoate
  参考文献：
  名称：

  Synthesis, Antibacterial Activity and Cytotoxicity of Novel Janus Peptide Dendrimers

  摘要：

  In an attempt to find new antibacterial agents, a series of well-defined Janus peptide dendrimers, which feature multiple anionic groups and amphiphilic structure, were synthesized and characterized in detail. The antibacterial activities of all the synthesized dendrimers were tested and screened by using the two-fold serial dilution method. Several compounds showed activity against E. coli, S. aureus, methicillin-resistant S. aureus, and E. faecalis. Further cytotoxicity assays showed that the antibacterial dendrimers were nontoxic against HEK293.

  DOI：

  10.1055/s-0031-1290403

文献信息

• Design and Synthesis of Novel Janus Dendrimers as Lipophilized Antioxidants
  作者：Li Guo、Junzhu Pan、Lifang Ma、Yi Zhao、Jing Zhao、Liang Ouyang

  DOI：10.1055/s-0032-1318457

  日期：——

  In the search for better antioxidants with more satisfactory lipophilicity, a series of Janus dendrimers that consisted of gallic acid and alkyl chains as the peripheral groups, were designed and synthesized. These dendrimers take advantage of a dendritic display to carry multi-antioxidants and multi-lipophilic moieties simultaneously. Consequently, the resulting dendrimers, which showed satisfactory lipophilicity and better antioxidant activity than the gallic acid monomer, are potential novel lipophilized antioxidant agents.