tert-butyl (3R)-3',3'-dicyano-1,5-dimethyl-5'-methylidene-2-oxospiro[indole-3,2'-pyrrolidine]-1'-carboxylate | 1429615-33-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl (3R)-3',3'-dicyano-1,5-dimethyl-5'-methylidene-2-oxospiro[indole-3,2'-pyrrolidine]-1'-carboxylate
• CAS: 1429615-33-7
• 化学式: C₂₁H₂₂N₄O₃
• 分子量: 378.431
• InChiKey: PXNFBKJUNULJLO-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  97.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  在 三氟化硼乙醚 、 2-二环己基膦-2′,4′,6′-三异丙基联苯金(I) 双(三氟甲烷磺酰)亚胺 作用下， 以 甲苯 为溶剂， 反应 8.5h， 生成 tert-butyl (3R)-3',3'-dicyano-1,5-dimethyl-5'-methylidene-2-oxospiro[indole-3,2'-pyrrolidine]-1'-carboxylate
  参考文献：
  名称：

  Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2′-oxindole] Derivatives

  摘要：

  An asymmetric organo- and gold-catalyzed one-pot sequential Mannich/hydroamination reaction has been developed. Using this protocol, spiro[pyrrolidin-3,2'-oxindole] derivatives were synthesized in good yields (up to 91%) and excellent enantioselectivities (up to 97% ee).

  DOI：

  10.1021/ol4004542

文献信息

• Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2′-oxindole] Derivatives
  作者：Xianjie Chen、Hui Chen、Xun Ji、Hualiang Jiang、Zhu-Jun Yao、Hong Liu

  DOI：10.1021/ol4004542

  日期：2013.4.19

  An asymmetric organo- and gold-catalyzed one-pot sequential Mannich/hydroamination reaction has been developed. Using this protocol, spiro[pyrrolidin-3,2'-oxindole] derivatives were synthesized in good yields (up to 91%) and excellent enantioselectivities (up to 97% ee).