Prop-2-ynyl 4-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-3-nitrobenzoate | 1428955-94-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Prop-2-ynyl 4-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-3-nitrobenzoate
• 英文别名: prop-2-ynyl 4-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-3-nitrobenzoate
• CAS: 1428955-94-5
• 化学式: C₁₆H₁₇NO₈
• 分子量: 351.313
• InChiKey: FCHUQRLBGVGAAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  139
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Prop-2-ynyl 4-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-3-nitrobenzoate 、 1,3,5-三(叠氮甲基)苯 在 copper(II) sulfate 、 sodium ascorbate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.33h， 以88%的产率得到[1-[[3,5-Bis[[4-[[4-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-3-nitrobenzoyl]oxymethyl]triazol-1-yl]methyl]phenyl]methyl]triazol-4-yl]methyl 4-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-3-nitrobenzoate
  参考文献：
  名称：

  Synthesis and Degradation of Backbone Photodegradable Polyester Dendrimers

  摘要：

  Dendrimers with fully photodegradable backbones were synthesized through the incorporation of photodegradable o-nitrobenzyl esters into a new dendrimer monomer based on 2,2-bis(hydroxymethyl)propionic acid (bis-MPA). Dendrons were synthesized using a divergent approach, and were subsequently coupled to a core molecule in the final step. Photodegradation was performed and it was demonstrated that the molecules degrade to release bis-MPA. The accessibility of these molecules opens new avenues for the preparation of well-defined, fully photodegradable materials.

  DOI：

  10.1021/ol4004367
• 作为产物：
  描述：

  4-溴甲基-3-硝基苯甲酸 在 4-二甲氨基吡啶 、 硫酸 、 caesium carbonate 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 生成 Prop-2-ynyl 4-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-3-nitrobenzoate
  参考文献：
  名称：

  Synthesis and Degradation of Backbone Photodegradable Polyester Dendrimers

  摘要：

  Dendrimers with fully photodegradable backbones were synthesized through the incorporation of photodegradable o-nitrobenzyl esters into a new dendrimer monomer based on 2,2-bis(hydroxymethyl)propionic acid (bis-MPA). Dendrons were synthesized using a divergent approach, and were subsequently coupled to a core molecule in the final step. Photodegradation was performed and it was demonstrated that the molecules degrade to release bis-MPA. The accessibility of these molecules opens new avenues for the preparation of well-defined, fully photodegradable materials.

  DOI：

  10.1021/ol4004367

文献信息

• Synthesis and Degradation of Backbone Photodegradable Polyester Dendrimers
  作者：Ali Nazemi、Tyler B. Schon、Elizabeth R. Gillies

  DOI：10.1021/ol4004367

  日期：2013.4.19

  Dendrimers with fully photodegradable backbones were synthesized through the incorporation of photodegradable o-nitrobenzyl esters into a new dendrimer monomer based on 2,2-bis(hydroxymethyl)propionic acid (bis-MPA). Dendrons were synthesized using a divergent approach, and were subsequently coupled to a core molecule in the final step. Photodegradation was performed and it was demonstrated that the molecules degrade to release bis-MPA. The accessibility of these molecules opens new avenues for the preparation of well-defined, fully photodegradable materials.