2-(3-fluoro-phenyl)-N-(2-isopropylsulfanyl-7-methyl-4-oxo-4H-thieno[3,2-d]pyrimidin-3-yl)-acetamide | 724447-96-5

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 2-(3-fluoro-phenyl)-N-(2-isopropylsulfanyl-7-methyl-4-oxo-4H-thieno[3,2-d]pyrimidin-3-yl)-acetamide
• 英文别名: 2-(3-fluorophenyl)-N-(7-methyl-4-oxo-2-propan-2-ylsulfanylthieno[3,2-d]pyrimidin-3-yl)acetamide
• CAS: 724447-96-5
• 化学式: C₁₈H₁₈FN₃O₂S₂
• 分子量: 391.49
• InChiKey: DAMLZSXKNMQNDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Quinazolinones as potassium channel modulators
  申请人：ICAgen, Inc.

  公开号：US20040198724A1

  公开（公告）日：2004-10-07

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.

  本发明提供了通过调节电压依赖性钾通道的钾离子通量来治疗疾病的化合物、组合物和方法。更具体地说，本发明提供了可用于治疗中枢或周围神经系统疾病（如偏头痛、共济失调、帕金森病、双相情感障碍）的喹唑啉酮、组合物和方法、偏头痛、共济失调、帕金森病、双相情感障碍、三叉神经痛、痉挛、情绪障碍、脑肿瘤、精神障碍、肌强直、癫痫发作、癫痫、听力和视力丧失、阿尔茨海默病、年龄相关性记忆丧失、学习缺陷、焦虑和运动神经元疾病），以及通过调节与所述病症发病或复发相关的钾离子通道作为神经保护剂（如预防中风等）。
• QUINAZOLINONES AS POTASSIUM CHANNEL MODULATORS
  申请人：Icagen, Inc.

  公开号：EP1585522B1

  公开（公告）日：2010-11-17
• EP1585522A4
  申请人：——

  公开号：EP1585522A4

  公开（公告）日：2006-08-09
• [EN] QUINAZOLINONES AS POTASSIUM CHANNEL MODULATORS<br/>[FR] QUINAZOLINONES COMME MODULATEURS DE CANAUX POTASSIQUES
  申请人：ICAGEN INC

  公开号：WO2004058704A2

  公开（公告）日：2004-07-15

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.